Visual areas exert feedforward and feedback influences through distinct frequency channels
Number of pages
SourceNeuron, 85, 2, (2015), pp. 390-401
Article / Letter to editor
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PI Group Neurobiology of Language
PI Group MR Techniques in Brain Function
Subject110 000 Neurocognition of Language; 120 000 Neuronal Coherence; 150 000 MR Techniques in Brain Function; 150 031 Building connectomes with MEG; Biophysics
Visual cortical areas subserve cognitive functions by interacting in both feedforward and feedback directions. While feedforward influences convey sensory signals, feedback influences modulate feedforward signaling according to the current behavioral context. We investigated whether these interareal influences are subserved differentially by rhythmic synchronization. We correlated frequency-specific directed influences among 28 pairs of visual areas with anatomical metrics of the feedforward or feedback character of the respective interareal projections. This revealed that in the primate visual system, feedforward influences are carried by theta-band (~4 Hz) and gamma-band (~60-80 Hz) synchronization, and feedback influences by beta-band (~14-18 Hz) synchronization. The functional directed influences constrain a functional hierarchy similar to the anatomical hierarchy, but exhibiting task-dependent dynamic changes in particular with regard to the hierarchical positions of frontal areas. Our results demonstrate that feedforward and feedback signaling use distinct frequency channels, suggesting that they subserve differential communication requirements.
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