Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers.
Publication year
2001Source
Psychiatry Research, 105, 3, (2001), pp. 151--63ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Psychiatry
SW OZ DCC CO
Journal title
Psychiatry Research
Volume
vol. 105
Issue
iss. 3
Page start
p. 151-
Page end
p. 63
Subject
Psychopathology and changed brain functions; Psychopathologie en veranderde hersenfunctiesAbstract
The mixed 5-HT receptor agonist/antagonist meta-chlorophenylpiperazine (mCPP) is known to suppress locomotor activity in mice and rats. This study aimed: (1) to determine whether mCPP induces cognitive and motor changes in normal human volunteers and how these changes relate to the neuroendocrine effects of mCPP; and (2) to compare these cognitive and motor changes to the known cognitive and motor slowing patterns in depression and schizophrenia. A computerized method (used in previous research) analyzed fine motor behavior during figure-copying tasks. In 14 normal male volunteers behavioral responses, body temperature, plasma levels of prolactin and cortisol, and cognitive and motor performance during figure-copying tasks were measured after a single oral dose of mCPP (0.5 mg/kg). mCPP-induced prolongation of the reaction times in all copying tasks, parallel to increases in cortisol and prolactin and some self-reported behavioral effects. There were no changes in the movement times or the velocities of the writing movements. In conclusion, mCPP induced cognitive, but not motor slowing, in normal male volunteers. This indicates that the human serotonin system is also implicated in psychomotor behavior. This pattern of slowing was different from that in depressed and schizophrenic patients.
This item appears in the following Collection(s)
- Academic publications [244084]
- Faculty of Medical Sciences [92872]
- Faculty of Social Sciences [30029]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.