Effect of oral acyclovir after penetrating keratoplasty for herpetic keratitis: a placebo-controlled multicenter trial.
Publication year
2003Source
Ophthalmology, 110, 10, (2003), pp. 1916-1919ISSN
Publication type
Article / Letter to editor

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Organization
Pharmacology-Toxicology
Ophthalmology
Journal title
Ophthalmology
Volume
vol. 110
Issue
iss. 10
Page start
p. 1916
Page end
p. 1919
Subject
UMCN 3.3: Neurosensory disordersAbstract
OBJECTIVE: To determine the prophylactic effect of oral acyclovir on the recurrence rate of herpetic eye disease after penetrating keratoplasty.
DESIGN: A randomized, double-masked, placebo-controlled multicenter trial.
PARTICIPANTS: Sixty-eight consecutive patients (68 eyes) with corneal opacities due to herpetic eye disease who underwent penetrating keratoplasty.
INTERVENTION: Oral acyclovir 400 mg twice daily or placebo tablets for 6 months.
MAIN OUTCOME MEASURES: The recurrence rate of herpetic eye disease-related events and rejection episodes, proven by viral cell culture or polymerase chain reaction. RESULTS: During the 2-year follow-up period, there were 3 culture-proven herpetic eye disease recurrences in the acyclovir group and 9 in the placebo group. Lifetime survival analysis of the probability of remaining free from recurrence revealed a significantly reduced risk of recurrent herpetic disease in the acyclovir-treated group.
CONCLUSION: This study suggests that oral acyclovir effectively prevents herpes-related recurrences after penetrating keratoplasty in herpetic eye disease.
This item appears in the following Collection(s)
- Academic publications [204860]
- Faculty of Medical Sciences [81031]
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