A multiantioxidant supplementation reduces damage from ischaemia reperfusion in patients after lower torso ischaemia. A randomised trial.

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Title:	A multiantioxidant supplementation reduces damage from ischaemia reperfusion in patients after lower torso ischaemia. A randomised trial.
Author(s):	Wijnen, M.H.W.A. ; Roumen, R.M.H.; Vader, H.L.; Goris, R.J.A.
Publication year:	2002
Source:	European Journal of Vascular and Endovascular Surgery, vol. 23, iss. 6, (2002), pp. 486-490
ISSN:	1078-5884
DOI:	https://doi.org/10.1053/ejvs.2002.1614
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/142769
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Subject:	Sepsis and non-bacterial generalized inflammation: causes and effects (sepsis and inflammation) Sepsis en niet-bacteriële gegeneraliseerde ontsteking: mogelijke oorzaken en gevolgen (sepsis en ontsteking)
Organization:	Surgery
Journal title:	European Journal of Vascular and Endovascular Surgery
Volume:	vol. 23
Issue:	iss. 6
Page start:	p. 486
Page end:	p. 490
Abstract:	BACKGROUND: open repair of intra-abdominal aortic aneurysm (AAA) is associated with lower torso ischaemia and reperfusion. OBJECTIVE: to examine the effect of antioxidants on the activation and sequestration of white blood cells and muscle injury during AAA repair. METHOD: forty-two patients undergoing elective infrarenal aneurysm repair, were randomised to either standard therapy (22 patients) or standard therapy with additional multiantioxidant supplementation (20 patients). Vitamin E and C, Allopurinol, N-acetylcysteine and mannitol was administered perioperatively. White blood cell count (WBC), serum creatine kinase, aspartateaminotransferase, lactate and lipofuscine were measured. RESULTS: WBC remained higher after reperfusion in the antioxidant group (p = 0.008). CK, ASAT and lipofuscine levels were significantly lower after reperfusion in the antioxidant group (p = 0.02, p = 0.018, p = 0.017). CONCLUSION: multi-antioxidant supplementation was associated with a reduction in serum CK and ASAT after AAA repair. This is likely due to a reduction in oxidative stress and a decreased leucocyte sequestration and activation.