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Title: Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma.
Author(s): Boesaard, E.P. ; Vogelaar, I.P.; Bult, P. ; Wauters, C.C.A.P.; Krieken, J.H.J.M. van ; Ligtenberg, M.J.L. ; Post, R.S. van der; Hoogerbrugge, N.
Publication year: 2014
Source: Hereditary Cancer in Clinical Practice, vol. 12, iss. 1, (2014), pp. 21
ISSN: 1731-2302
DOI: https://doi.org/10.1186/1897-4287-12-21
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/142721   https://hdl.handle.net/2066/142721

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Subject: Radboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Paediatrics - OUD tm 2017
Human Genetics
Pathology
Medical Oncology
Journal title:
Hereditary Cancer in Clinical Practice
Volume: vol. 12
Issue: iss. 1
Page start: p. 21
Abstract:
MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identified, indicating that biallelic MUTYH mutations are not a frequent underlying cause for the development of papillary carcinomas of the breast.

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