Two cases of subcutaneous Scedosporium apiospermum infection treated with voriconazole.

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Title:	Two cases of subcutaneous Scedosporium apiospermum infection treated with voriconazole.
Author(s):	Bosma, F.; Voss, A. ; Hamersvelt, H.W. van ; Sevaux, R.G.L. de ; Biert, J. ; Kullberg, B.J. ; Melchers, W.J.G. ; Verweij, P.E.
Publication year:	2003
Source:	Clinical Microbiology and Infection, vol. 9, iss. 7, (2003), pp. 750-753
ISSN:	1198-743X
DOI:	http://dx.doi.org/10.1046/j.1469-0691.2003.00596.x
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/142708
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Subject:	EBP 3: Effective Primary Care and Public Health UMCN 4.1: Microbial pathogenesis and host defense UMCN 5.4: Renal disorders
Organization:	Medical Microbiology Nephrology Surgery Internal Medicine
Journal title:	Clinical Microbiology and Infection
Volume:	vol. 9
Issue:	iss. 7
Page start:	p. 750
Page end:	p. 753
Abstract:	Scedosporium apiospermum is a mold that is increasingly being recognized as an opportunistic pathogen in immunocompromised patients, and treatment is complicated by intrinsic resistance to several antifungal agents. In our hospital, two cases of S. apiospermum infection occurring within 2 weeks were successfully treated with voriconazole. Since both patients were infected with an uncommon pathogen, a search for a common nosocomial source was performed. As environmental cultures yielded no S. apiospermum, and random amplified polymorphic DNA (RAPD) fingerprinting showed that the patients' strains were genotypically unrelated, we considered a common nosocomial source of S. apiospermum to be unlikely.