Magnetization transfer effect on the creatine methyl resonance studied by CW off-resonance irradiation in human skeletal muscle on a clinical MR system.
SourceMagnetic Resonance in Medicine, 50, 3, (2003), pp. 468-73
Article / Letter to editor
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Cell Biology (UMC)
Magnetic Resonance in Medicine
SubjectUMCN 1.1: Functional Imaging; UMCN 5.3: Cellular energy metabolism
Magnetization transfer (MT) between the mobile (MR-visible) spin pool and immobile (MR-invisible) spin pool of creatine (Cr) was studied on a clinical 1.5 T MR scanner in human skeletal muscle using continuous wave (CW) pre-irradiation as the saturation method for the immobile pool. For this purpose, only slight modifications to the MR system were made. A specially designed electronic circuit was used to couple a CW amplifier to the RF channel of the scanner. The CW pulse power (gammaB(2)/2pi) and pulse length were determined to be approximately 550 Hz and 3 s, respectively, for optimal signal attenuation of the Cr methyl signal. The bound Cr fraction in human gastrocnemius muscle was determined to be 0.4-1.3% using a two-pool exchange model function to describe the MT effect.
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- Faculty of Medical Sciences 
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