The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells.

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Title:	The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells.
Author(s):	Cambi, A. ; Gijzen, K.; Vries, J.M. de; Torensma, R. ; Joosten, B.H.G.M. ; Adema, G.J. ; Netea, M.G. ; Kullberg, B.J. ; Romani, L.; Figdor, C.G.
Publication year:	2003
Source:	European Journal of Immunology, vol. 33, iss. 2, (2003), pp. 532-538
ISSN:	0014-2980
DOI:	https://doi.org/10.1002/immu.200310029
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/142347
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Subject:	EBP 3: Effective Primary Care and Public Health UMCN 1.3: Tumor microenvironment UMCN 4.1: Microbial pathogenesis and host defense
Organization:	Tumorimmunology Internal Medicine
Journal title:	European Journal of Immunology
Volume:	vol. 33
Issue:	iss. 2
Page start:	p. 532
Page end:	p. 538
Abstract:	Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans, the major cause of hospital-acquired fungal infections, penetrates at similar submucosal sites. Here we demonstrate that DC-SIGN is able to bind C. albicans both in DC-SIGN-transfected cell lines and in human monocyte-derived DC. The binding was shown to be time- as well as concentration-dependent, and live as well as heat-inactivated C. albicans were bound to the same extent. Moreover, in immature DC, DC-SIGN was able to internalize C. albicans in specific DC-SIGN-enriched vesicles, distinct from those containing the mannose receptor, the other known C. albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi.