[Tuberculosis and HIV coinfection in three patients: the possibilities for simultaneous treatment]

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Title:	[Tuberculosis and HIV coinfection in three patients: the possibilities for simultaneous treatment]
Author(s):	Oosterhout, J.J.G. van; Boeree, M.J. ; Burger, D.M. ; Lange, W.C.M. de ; Crevel, R. van ; Koopmans †, P.P.
Publication year:	2003
Source:	Nederlands Tijdschrift voor Geneeskunde, vol. 147, iss. 9, (2003), pp. 369-372
ISSN:	0028-2162
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/141341
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Subject:	EBP 3: Effective Primary Care and Public Health UMCN 2.1: Heart, lung and circulation UMCN 4.1: Microbial pathogenesis and host defense
Organization:	Internal Medicine Pulmonary Diseases Clinical Pharmacy
Journal title:	Nederlands Tijdschrift voor Geneeskunde
Volume:	vol. 147
Issue:	iss. 9
Page start:	p. 369
Page end:	p. 372
Abstract:	Three patients received simultaneous treatment for tuberculosis and HIV: a 23-year-old woman and a 33-year-old man who were asylum seekers from Africa and a 45-year-old woman who was an intravenous drug addict. During the treatment with antiretroviral and anti-tuberculous drugs, several problems arose: drug interactions (between rifampicine and protease inhibitors/non-nucleoside reverse transcriptase inhibitors), side effects, non-compliance and immune reconstitution reactions. These problems were solved either by temporary withdrawal of the medication or by substituting other drugs. There are a number of possible treatment strategies that minimise the risks. Despite the potential problems, in patients with advanced HIV infection, antiretroviral treatment should not be delayed until after the end of the tuberculosis treatment.