Cerebrovascular response to acute metabolic acidosis in humans.

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Title:	Cerebrovascular response to acute metabolic acidosis in humans.
Author(s):	Ven, M.T.P. van de ; Colier, W.N.J.M. ; Kersten, B.T.P. ; Oeseburg, B.; Folgering, H.T.M.
Publication year:	2003
Source:	Advances in Experimental Medicine and Biology, vol. 530, (2003), pp. 707-715
ISSN:	0065-2598
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/140194
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Subject:	EBP 2: Effective Hospital Care UMCN 2.1: Heart, lung and circulation UMCN 2.2: Vascular medicine and diabetes
Organization:	Nuclear Medicine Physiology Pulmonary Diseases
Journal title:	Advances in Experimental Medicine and Biology
Volume:	vol. 530
Page start:	p. 707
Page end:	p. 715
Abstract:	OBJECTIVES: Evaluation of the cerebrovascular response (delta CBV/delta PaCO2) during baseline metabolic conditions and acute metabolic acidosis. METHODS: 15 healthy subjects, 5 m, 10 f, 56 +/- 10 yrs were investigated. For acidification, NH4Cl was given orally. CBV was measured using Near Infrared Spectroscopy (OXYMON) during normo-, hyper- and hypocapnia. RESULTS: Acute metabolic acidosis was realised: mean delta BE -2.7 mEq.L-1 (p < 0.001) with mean delta PaCO2 -0.2 kPa (p < 0.01). During normo-, hyper- and hypocapnia, CBV values of 3.51, 4.82 and 2.55 mL.100 g-1 were calculated during baseline metabolic conditions and 3.70, 4.86 and 2.63 mL.100 g-1 during acute metabolic acidosis. The CBV/PaCO2 response showed a hockeystick configuration with the point of infliction around normocapnia. delta CBV/delta PaCO2 reactivity from normo- to hypercapnia and from normo- to hypocapnia was calculated; no significant differences in delta CBV/delta PaCO2 were found in both metabolic conditions. CONCLUSION: Cerebrovascular reactivity to CO2 does not alter during acute metabolic acidosis.