S100B protein, glia and Gilles de la Tourette syndrome.
SourceEuropean Journal of Paediatric Neurology, 5, 1, (2001), pp. 15-9-9
Article / Letter to editor
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Paediatrics - OUD tm 2017
European Journal of Paediatric Neurology
SubjectDisturbances of cerebral development in the young child.; Epidemiology; Neuromuscular and neurometabolic disorders; Pathophysiology of Brain and Behaviour; Cerebrale ontwikkelingsstoornissen bij het jonge kind; Epidemiologie; Neuromusculaire en neurometabole aandoeningen; Pathofysiologie van Hersenen en Gedrag
Activated glial cells play an important role in a variety of neurological disorders. This study examines S100B protein levels in the serum of patients with Gilles de la Tourette syndrome, as potential marker for glial cell function. Two groups of children were examined: 61 reference patients and 33 patients with Gilles de la Tourette syndrome. It was found that S100B serum concentrations in the reference group decrease with increasing age. Furthermore it was found that the mean S100B concentration in serum of children with Gilles de la Tourette syndrome is significantly higher than in the reference group. These preliminary results suggest that glial tissue might be involved in the pathophysiology of the syndrome.
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