Cardiovascular effects of aerobic exercise training in formerly preeclamptic women and healthy parous control subjects
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Publication year
2014Source
American Journal of Obstetrics and Gynecology, 211, 5, (2014), pp. 516 e1-516 e11ISSN
Publication type
Article / Letter to editor
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Organization
Gynaecology
Physiology
Journal title
American Journal of Obstetrics and Gynecology
Volume
vol. 211
Issue
iss. 5
Page start
p. 516 e1
Page end
p. 516 e11
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences; Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences; Radboudumc 6: Metabolic Disorders RIHS: Radboud Institute for Health SciencesAbstract
OBJECTIVE: Women who have had preeclampsia demonstrate higher prevalence of metabolic syndrome (MetS), impaired vascular function, and increased sympathetic activity and are at increased risk of cardiovascular disease. The aim of this study was to assess the effects of 12 weeks of exercise training (70-80% maximum volume of oxygen utilization) in women who had had preeclampsia on physical fitness, components of MetS, vasculature, and autonomic functions compared with healthy control subjects. STUDY DESIGN: Our prospective case-control study included 24 normotensive women who had had preeclampsia and 20 control subjects who were matched for age and postpartum interval (all 6-12 months after delivery). Before and after training, we measured all components of MetS (ie, BP, lipids, glucose/insulin, and albuminuria), carotid intima media thickness (IMT) and brachial and superficial femoral artery endothelial function that used flow-mediated dilation (FMD). Autonomic activity was quantified with power spectral analysis (low-frequency/high-frequency power [LF/HF] ratio). RESULTS: At baseline, women who had had preeclampsia demonstrated higher values of most components of MetS. Compared with the control subjects, women who had had preeclampsia had increased IMT (580 +/- 92 mum vs 477 +/- 65 mum, respectively), impaired endothelial function (FMD brachial artery, 5.3% +/- 2.2% vs 10.8% +/- 3.5%, respectively; FMD superficial femoral artery, 4.9% +/- 2.1% vs 8.7% +/- 3.2%, respectively) and increased LF/HF power ratio (2.2 +/- 1.0 vs 1.3 +/- 0.4, respectively; all P < .05). In both groups, exercise training decreased values of most components of MetS and IMT, improved FMD, and concurrently reduced LF/HF. Despite these improvements, vascular and autonomic variables did not normalize by 12 weeks of training in women who had had preeclampsia. CONCLUSION: This study demonstrates that exercise training in women who had had preeclampsia and control subjects improves components of MetS, endothelial function, vascular wall thickness, and autonomic control. Nonetheless, trained women who had had preeclampsia only reached a cardiovascular status that is comparable with sedentary healthy control subjects.
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- Academic publications [244084]
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- Faculty of Medical Sciences [92872]
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