[The anti-synthetase syndrome: muscle disease and multisystem disorder at the same time]
SourceNederlands Tijdschrift voor Geneeskunde, 147, 31, (2003), pp. 1485-1489
Article / Letter to editor
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Nederlands Tijdschrift voor Geneeskunde
SubjectBio-Molecular Chemistry; UMCN 3.1: Neuromuscular development and genetic disorders; UMCN 4.2: Chronic inflammation and autoimmunity
In three women, aged 60, 45 and 38 years, who presented with exertional dyspnoea (due to lung fibrosis) and Raynaud's phenomenon, dermatomyopathy and Raynaud's phenomenon, and symmetrical arthralgia and myalgia, respectively, the anti-synthetase syndrome was diagnosed. The anti-synthetase syndrome consists of myositis, idiopathic interstitial lung disease, polyarthritis and Raynaud's phenomenon. The syndrome is characterised by the presence of autoantibodies directed against aminoacyl-tRNA synthetases. A thorough knowledge of this syndrome is required to anticipate manifestations of the disease, which can sometimes be masked and are not always part of the treating physician's field of specialty. The patients were treated with immunosuppressive therapy (azathioprine, prednisone, methotrexate) and recovered considerably.
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