Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
Publication year
2014Source
Pediatric Research, 75, 1-2, (2014), pp. 184-8ISSN
Publication type
Article / Letter to editor
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Organization
Internal Medicine
Journal title
Pediatric Research
Volume
vol. 75
Issue
iss. 1-2
Page start
p. 184
Page end
p. 8
Subject
Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Unique features of immunity early in life include a distinct immune system particularly reliant on innate immunity, with weak T helper (Th)1-polarizing immune responses, and impaired responses to certain vaccines leading to a heightened susceptibility to infection. To these important aspects, we now add an increasingly appreciated concept that the innate immune system displays epigenetic memory of an earlier infection or vaccination, a phenomenon that has been named "trained immunity." Exposure of neonatal leukocytes in vitro or neonatal animals or humans in vivo to specific innate immune stimuli results in an altered innate immune set point. Given the particular importance of innate immunity early in life, trained immunity to early life infection and/or immunization may play an important role in modulating both acute and chronic diseases.
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- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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