A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

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Title:	A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers
Author(s):	Thaler, A.; Artzi, M.; Mirelman, A.; Jacob, Y.; Helmich, R.C.G. ; Nuenen, B.F.L. van ; Gurevich, T.; Orr-Urtreger, A.; Marder, K.; Bressman, S.; Bloem, B.R. ; Hendler, T.; Giladi, N.; Bashat, D. Ben; et al.
Publication year:	2014
Source:	Movement Disorders, vol. 29, iss. 6, (2014), pp. 823-827
ISSN:	0885-3185
DOI:	https://doi.org/10.1002/mds.25827
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/138029
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Subject:	Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience
Organization:	Neurology Donders Centre for Cognitive Neuroimaging
Journal title:	Movement Disorders
Volume:	vol. 29
Issue:	iss. 6
Page start:	p. 823
Page end:	p. 827
Abstract:	BACKGROUND: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. METHODS: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. RESULTS: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. CONCLUSIONS: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.