Author(s):
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Thaler, A.; Artzi, M.; Mirelman, A.; Jacob, Y.;
Helmich, R.C.G.
;
Nuenen, B.F.L. van
; Gurevich, T.; Orr-Urtreger, A.; Marder, K.; Bressman, S.;
Bloem, B.R.
; Hendler, T.; Giladi, N.; Bashat, D. Ben; et al.
|
Subject:
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Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience |
Organization:
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Neurology Donders Centre for Cognitive Neuroimaging |
Abstract:
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BACKGROUND: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. METHODS: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. RESULTS: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. CONCLUSIONS: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.
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