TY - THES AU - Brouwers, F.M. PY - 2008 SN - 9789090231471 UR - https://hdl.handle.net/2066/71138 PB - [S.l. : s.n.] TI - Molecular and clinical studies of pheochromocytomas and catecholamine-producing paragangliomas. N1 - RU Radboud Universiteit Nijmegen, 30 juni 2008 N1 - Promotores : Lenders, J.W.M., Pacak, K. Co-promotor : Timmers, H.J.L.M. PS - 144 p. ER - TY - THES AU - Hofstede, H.J.M. ter PY - 2008 SN - 9789090235509 UR - https://hdl.handle.net/2066/71398 PB - [S.l. : s.n.] TI - Clinical aspects of toxicity in antiretroviral therapy. N1 - RU Radboud Universiteit Nijmegen, 9 december 2008 N1 - Promotor : Meer, J.W.M. van der Co-promotores : Koopmans †, P.P., Burger, D.M. PS - 150 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/71398/71398.pdf?sequence=1 ER - TY - THES AU - Kasteren, M.E.E. van PY - 2008 SN - 9789090225081 UR - https://hdl.handle.net/2066/32072 AB - This thesis comprises several studies on the implementation of guidelines for antimicrobial use in prophylaxis as well as in therapy. The main part focuses on the data of the CHIPS-study; a quality improvement project of surgical prophylaxis in the Netherlands promoting prudent use of antibiotics and implementing the national guideline for prophylaxis of the Ducth Working Party of Antibiotic Policy (SWAB). Thirteen hospitals, in four surgical disciplines, participated in the study. Audits in the hospitals showed that in general the willingness to adhere to local guidelines for prophylaxis was good, although adherence to guidelines for timing was problematic. Implementation of the SWAB-guideline for prophylaxis resulted in significant improvements: increased use of narrow spectrum antibiotics, shorter duration of prophylaxis and correct timing. A significant decrease in total antimicrobial use and costs was achieved while maintaining efficacy in terms of preventing surgical site infections (SSI). Barriers for change varied per parameter of surgical prophylaxis and between hospitals and surgical specialties. There was no magic improvement strategy and identifying key players for change was essential for success. In total hip arthroplasty it was shown that, although not statistically significant, timing of prophylaxis seems to be the most relevant prophylaxis parameter that influences patient outcome in terms of SSI. Timely administration of antibiotics also effects patient outcome in antibiotic therapy, and an intervention study in an University Hospital showed that the delay between the order and administration of the first dose of the antibiotic could be signifcantly shortened. In conclusion important improvements in the quality of surgical prophylaxis and therapy could be achieved and, even in a country with a history of prudent antibiotic use, cost savings could be obtained in prophylaxis while maintaining efficacy in terms of prevention of SSI PB - [S.l. : s.n.] TI - Improving the prescription of antibiotics, focus on surgical prophylaxis. N1 - RU Radboud Universiteit Nijmegen, 16 januari 2008 N1 - Promotores : Kullberg, B.J., Meer, J.W.M. van der Co-promotor : Gyssens, I.C.J. PS - 199 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/32072/32072_imprthpro.pdf?sequence=1 ER - TY - THES AU - Knoop, J.A. PY - 2008 SN - 9789090227863 UR - https://hdl.handle.net/2066/65596 PB - [S.l. : s.n.] TI - Cognitive behaviour therapy for chronic fatigue syndrome: Analysis of the treatment response. N1 - RU Radboud Universiteit Nijmegen, 3 april 2008 N1 - Promotores : Bleijenberg, G., Meer, J.W.M. van der PS - 135 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/65596/65596_cognbethf.pdf?sequence=1 ER - TY - THES AU - Gielissen, M.F.M. PY - 2008 SN - 9789090224824 UR - https://hdl.handle.net/2066/45169 PB - [S.l. : s.n.] TI - Fatigue in cancer survivors. From assessment to cognitive behaviour therapy. N1 - RU Radboud Universiteit Nijmegen, 17 januari 2008 N1 - Promotores : Bleijenberg, G., Mulder, P.H.M. de Co-promotor : Verhagen, C.A.H.H.V.M. PS - 181 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/45169/45169_fatiincas.pdf?sequence=1 ER - TY - THES AU - Oosterhout, J.J.G. van PY - 2008 SN - 9789090236230 UR - https://hdl.handle.net/2066/69127 PB - [S.l. : s.n.] TI - Management of HIV infection in Malawi. N1 - RU Radboud Universiteit Nijmegen, 22 december 2008 N1 - Promotores : Meer, J.W.M. van der, Zijlstra, E.E PS - 192 p. ER - TY - THES AU - Diepeveen, S.H.A. PY - 2008 SN - 9789074991568 UR - https://hdl.handle.net/2066/32088 PB - [S.l. : s.n.] TI - Oxidative Stress in End-Stage Renal Disease. N1 - 27 maart 2008 N1 - Promotores : Stalenhoef, A.F.H., Bilo, H.J. Co-promotor : Tits, L.J.H. van PS - 113 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/32088/32088_oxidstine.pdf?sequence=1 ER - TY - THES AU - Buijs, J. PY - 2008 SN - 9789090229911 UR - https://hdl.handle.net/2066/71502 PB - [S.l. : s.n.] TI - Bacterial morphology and cytokine responses during initial treatment of Gram-negative sepsis. N1 - RU Radboud Universiteit Nijmegen, 30 mei 2008 N1 - Promotor : Meer, J.W.M. van der Co-promotores : Dofferhoff, A.S.M., Mouton, J.W. PS - 143 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/71502/71502.pdf?sequence=1 ER -