TY - THES AU - Dooper, M.M.B.W. PY - 2004 UR - https://hdl.handle.net/2066/58884 PB - [S.l. : s.n.] TI - Immuno-modulation by polyunsaturated fatty acids : focus on dihomo-y-linolenic acid. N1 - KUN, 5 maart 2004 N1 - Promotor : Meer, J.W.M. van der Co-promotor : Rabet, L. M' PS - 124 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/58884/58884.pdf?sequence=1 ER - TY - THES AU - Vonk, A.G. PY - 2004 SN - 9090184155 UR - https://hdl.handle.net/2066/19512 AB - The yeast Candida albicans is the primary etiologic agent of disseminated and invasive candidiasis. The incidence of disseminated and invasive candidiasis has paralleled the use of modern medical procedures that adversely affect the immune system, and highlights the difficulty of treating disseminated and invasive candidiasis. Overcoming these difficulties requires an improved understanding of host - C. albicans interactions. The most important aspect of these interactions is the host defence system. The nature and extent of the impairment of the host resistance determines the pattern of candidiasis. A better understanding of the mechanisms responsible for the defence against disseminated and invasive Candida infection is needed, in order to develop strategies aimed to enforce the anticandidal actions of the immune system. In this thesis, studies on host defence against disseminated and invasive candidiasis (intra-abdominal Candida abscesses) are described. Central to these studies are the contribution of phagocytes and lymphocytes to host defence, the mechanisms through which endogenous pro-inflammatory cytokines exert their effects, and the influence of antifungal agents with or without immunomudolating substances such as granulocyte colony stimulating factor on host defence. The results of these studies aid in predicting the impact of the current immonotherapies and the development of future immunomodulating strategies. PB - [S.l. : s.n.] TI - Host defence against disseminated and invasive candida albicans infections. N1 - KUN Katholieke Universiteit Nijmegen, 18 oktober 2004 N1 - Promotores : Kullberg, B.J., Meer, J.W.M. van der Co-promotor : Netea, M.G. PS - 203 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/19512/19512.pdf?sequence=1 ER - TY - THES AU - Veerkamp, M.J. PY - 2004 SN - 9090186956 UR - https://hdl.handle.net/2066/59038 AB - Familial Combined Hyperlipidemia (FCH) is the most common inherited hyperlipidemia in humans with an increased risk of cardiovascular disease (CVD). Therefore, it is of great importance to identify and treat subjects with FCH appropriately. The exact pathophysiology of FCH is still unknown, also the genetic basis for FCH has remained obscure. The search for metabolic and genetic origin of this lipid disorder has some fundamental problems. Not all research groups use the same criteria to establish the diagnosis FCH, and the lipid phenotype can vary substantially within any individual. The main aim of this thesis was to evaluate this intra-individual variation in lipid phenotype over a period of 5 year and to come to more consistent and unequivocal diagnostic criteria for FCH which can be used in clinical practice. The diagnosis FCH based on plasma total cholesterol and triglycerides, both adjusted for age and gender was consistent in only 74% of the subjects over a 5-year period. It appeared that the combination of absolute apoB level, triglyceride concentration and total cholesterol concentration, both adjusted for age and gender most adequately predict FCH. To facilitate the implementation of these new diagnostic criteria in clinical practice we developed a nomogram to simply and accurately diagnose FCH. Furthermore, we investigated the contribution of other metabolic parameters and factors (like homocysteine, insulin resistance and leptin) in relation to FCH phenotype and the increased risk of CVD and presented a review about the pathogenesis of FCH with emphasis on the role of insulin resistance, adipose tissue metabolism and fatty acids. PB - [S.l. : s.n.] TI - Familial Combined Hyperlipidemia: metabolic features and new diagnostic criteria. N1 - KUN Katholieke Universiteit Nijmegen, 8 december 2004 N1 - Promotor : Stalenhoef, A.F.H. Co-promotor : Graaf, J. de PS - 165 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/59038/59038.pdf?sequence=1 ER - TY - THES AU - Simon, A. PY - 2004 SN - 9090184325 UR - https://hdl.handle.net/2066/58960 AB - The subject of this thesis is a group of rare hereditary disorders, collectively called auto-inflammatory syndromes, with a specific focus on the hyper-IgD and periodic fever syndrome. The autoinflammatory syndromes are characterized by lifelong recurrent episodes with fever, usually accompanied by other inflammatory symptoms such as abdominal pain, diarrhoea, rash or arthralgia. The inflammatory episodes are separated by symptom-free intervals. This thesis explores several issues involving diagnosis, pathogenesis and treatment of the hyper-IgD and periodic syndrome, TNF-receptor associated periodic syndrome and familial Mediterranean fever syndrome. PB - [S.l. : s.n.] TI - Hereditary autoinflammatory syndromes -with emphasis on Hyper IgD and periodic fever syndrome- N1 - KUN Katholieke Universiteit Nijmegen, 4 november 2004 N1 - Promotor : Meer, J.W.M. van der Co-promotor : Drenth, J.P.H. PS - 206 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/58960/58960.pdf?sequence=1 ER - TY - THES AU - Timmers, H.J.L.M. PY - 2004 SN - 9090180486 UR - https://hdl.handle.net/2066/59116 AB - Carotid baro- and chemoreceptors play an important role in blood pressure and blood gas homeostasis. Inadvertent denervation of these receptors in humans has been reported following surgery and radiotherapy in the area of the carotid bifurcation. The resulting syndrome of baroreflex failure is characterized by disabling labile hypertension. Chemoreflex failure results in abnormal ventilatory responsiveness to hypoxia. This thesis contains studies on the long-term effects of carotid body tumor surgery, carotid endarterectomy and jugular radiotherapy on baro- and chemoreflex function. The relative contribution of carotid receptors to baro- and chemoreflex function in humans is discussed PB - [S.l. : s.n.] TI - Denervation of carotid baro- and chemoreceptors in humans. N1 - KUN Katholieke Universiteit Nijmegen, 23 juni 2004 N1 - Promotor : Thien, Th. Co-promotores : Lenders, J.W.M., Karemaker, J.M., Wieling, W. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/59116/59116.pdf?sequence=1 ER -