TY - JOUR AU - Simon, A. AU - Bijzet, J. AU - Voorbij, H.A.M. AU - Mantovani, A. AU - Meer, J.W.M. van der AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/13822 PB - Blackwell publishing ltd TI - Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response EP - 253 SN - 0954-6820 IS - iss. 3 SP - 247 JF - Journal of Internal Medicine VL - vol. 256 ER - TY - JOUR AU - Netea, M.G. AU - Graaf, C. van der AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/13837 PB - Federation amer soc exp biol TI - Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system EP - 755 SN - 0741-5400 IS - iss. 5 SP - 749 JF - Journal of Leukocyte Biology VL - vol. 75 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/13837/13837.pdf?sequence=1 ER - TY - JOUR AU - Sprong, T. AU - Netea, M.G. AU - Ley, P. van der AU - Verver-Jansen, T.J.G. AU - Jacobs, L.E.H. AU - Stalenhoef, A. AU - Meer, J.W.M. van der AU - Deuren, M. van PY - 2004 UR - https://hdl.handle.net/2066/13818 PB - Lipid research inc TI - Human lipoproteins have divergent neutralizing effects on E-coli LPS, N-meningitidis LPS, and complete Gram-negative bacteria EP - 749 SN - 0022-2275 IS - iss. 4 SP - 742 JF - Journal of Lipid Research (Online) VL - vol. 45 ER - TY - JOUR AU - Stuyt, P.M.J. AU - Graaf, J. de AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/13816 PB - Van zuiden communications TI - Who does become an internist? EP - 101 SN - 0300-2977 IS - iss. 3 SP - 98 JF - Netherlands Journal of Medicine VL - vol. 62 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/13816/13816.pdf?sequence=1 ER - TY - JOUR AU - Simon, A. AU - Kremer, H.P.H. AU - Wevers, R.A. AU - Scheffer, H. AU - Jong, J.G. de AU - Meer, J.W.M. van der AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/13821 PB - Lippincott williams & wilkins TI - Mevalonate kinase deficiency - Evidence for a phenotypic continuum EP - 997 SN - 0028-3878 IS - iss. 6 SP - 994 JF - Neurology VL - vol. 62 ER - TY - JOUR AU - Netea, M.G. AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/13840 PB - Elsevier science london TI - Toll-like receptors as an escape mechanism from the host defense EP - 488 SN - 0966-842X IS - iss. 11 SP - 484 JF - Trends in Microbiology VL - vol. 12 ER - TY - JOUR AU - Mirre, E. van AU - Teeling, J.L. AU - Meer, J.W.M. van der AU - Meeker, W.K. AU - Hack, C.E. PY - 2004 UR - https://hdl.handle.net/2066/13844 PB - Amer assoc immunologists TI - Monomeric IgG in intravenous Ig preparations is a functional antagonist of Fc gamma RII and Fc gamma RIIIb EP - 339 SN - 0022-1767 IS - iss. 1 SP - 332 JF - Journal of Immunology VL - vol. 173 ER - TY - JOUR AU - Crevel, R. van AU - Doorninck, D.J. van AU - Ams, J.E. van AU - Tjon Kon Fat, H. AU - Vreden, S.G.S. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/13868 TI - Tuberculose onder Trio-indianen in Suriname EP - 429 SN - 0028-2162 IS - iss. 9 SP - 425 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 148 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Kleijn, E.M.H.A. de AU - Corstens, F.H.M. AU - Meer, J.W.M. van der AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/13877 PB - Springer-verlag TI - Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation EP - 37 SN - 1619-7070 IS - iss. 1 SP - 29 JF - European Journal of Nuclear Medicine and Molecular Imaging VL - vol. 31 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Corstens, F.H.M. AU - Meer, J.W.M. van der AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/13878 PB - Springer TI - Fever of unknown origin: prospective comparison of diagnostic value of F-18-FDG PET and In-111-granulocyte scintigraphy EP - 1343 SN - 1619-7070 IS - iss. 9 SP - 1342 JF - European Journal of Nuclear Medicine and Molecular Imaging VL - vol. 31 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Jager, G. AU - Tack, C.J. AU - Meer, J.W.M. van der AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/13879 PB - Blackwell publishing ltd TI - F-18-fluorodeoxyglucose positron emission tomography leading to a diagnosis of septic thrombophlebitis of the portal vein: description of a case history and review of the literature EP - 423 SN - 0954-6820 IS - iss. 3 SP - 419 JF - Journal of Internal Medicine VL - vol. 255 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Bredie, S.J.H. AU - Meer, J.W.M. van der AU - Corstens, F.H.M. AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/13880 TI - Fluorine 18 fluorodeoxyglucose positron emission tomography in the diagnosis and follow-up of three patients with vasculitis EP - 53 SN - 0002-9343 IS - iss. 1 SP - 50 JF - American Journal of Medicine VL - vol. 116 ER - TY - JOUR AU - Netea, M.G. AU - Gijzen, K. AU - Coolen, N. AU - Verschueren, I. AU - Figdor, C.G. AU - Meer, J.W.M. van der AU - Torensma, R. AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/27251 PB - Elsevier science bv TI - Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages EP - 989 SN - 1286-4579 IS - iss. 11 SP - 985 JF - Microbes and Infection VL - vol. 6 ER - TY - JOUR AU - Vonk, A.G. AU - Bont, N. de AU - Netea, M.G. AU - Demacker, P.N.M. AU - Meer, J.W.M. van der AU - Stalenhoef, A.F.H. AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/13807 PB - Taylor & francis ltd TI - Apolipoprotein-E-deficient mice exhibit an increased susceptibility to disseminated candidiasis EP - 348 SN - 1369-3786 IS - iss. 4 SP - 341 JF - Medical Mycology VL - vol. 42 ER - TY - JOUR AU - Simon, A. AU - Bodar, E.J. AU - Hilst, J.C.H. van der AU - Meer, J.W.M. van der AU - Fiselier, T.J.W. AU - Cuppen, M.P.J.M. AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/13823 TI - Beneficial response to interleukin I receptor antagonist in traps EP - 210 SN - 0002-9343 IS - iss. 3 SP - 208 JF - American Journal of Medicine VL - vol. 117 ER - TY - JOUR AU - Sprong, T. AU - Jack, D.L. AU - Klein, N.J. AU - Turner, M.W. AU - Ley, P. van der AU - Steeghs, L. AU - Jacobs, L. AU - Meer, J.W.M. van der AU - Deuren, M. van PY - 2004 UR - https://hdl.handle.net/2066/13819 PB - Academic press ltd elsevier science ltd TI - Mannose binding lectin enhances IL-1 beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis EP - 66 SN - 1043-4666 IS - iss. 2 SP - 59 JF - Cytokine VL - vol. 28 ER - TY - JOUR AU - Meer, J.W.M. van der AU - Lamberts, S.W.J. AU - Buchwald, D. PY - 2004 UR - https://hdl.handle.net/2066/13846 PB - Blackwell publishing ltd TI - Dr Baschetti rides/writes again EP - 317 SN - 0014-2972 IS - iss. 4 SP - 317 JF - European Journal of Clinical Investigation VL - vol. 34 ER - TY - JOUR AU - Netea, M.G. AU - Hijmans, A. AU - Wissen, S. van AU - Smilde, T.J. AU - Trip, M.D. AU - Kullberg, B.J. AU - Boo, T. de AU - Meer, J.W.M. van der AU - Kastelein, J.J.P. AU - Stalenhorf, A.F.H. PY - 2004 UR - https://hdl.handle.net/2066/13834 PB - Blackwell publishing ltd TI - Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia EP - 99 SN - 0014-2972 IS - iss. 2 SP - 94 JF - European Journal of Clinical Investigation VL - vol. 34 ER - TY - JOUR AU - Netea, M.G. AU - Hijmans, A. AU - Wissen, S. van AU - Smilde, T.J. AU - Trip, M.D. AU - Kullberg, B.J. AU - Boo, T. de AU - Meer, J.W.M. van der AU - Kastelein, J.J.P. AU - Stalenhoef, A.F.H. PY - 2004 UR - https://hdl.handle.net/2066/13838 PB - Blackwell publishing ltd TI - Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolemia (Erratum: vol 34, pg 94, 2004) EP - 322 SN - 0014-2972 IS - iss. 4 SP - 322 JF - European Journal of Clinical Investigation VL - vol. 34 ER - TY - JOUR AU - Netea, M.G. AU - Graaf, C. van der AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/13841 PB - Springer TI - Recognition of fungal pathogens by Toll-like receptors EP - 676 SN - 0934-9723 IS - iss. 9 SP - 672 JF - European Journal of Clinical Microbiology and Infectious Diseases VL - vol. 23 ER - TY - JOUR AU - Wieringa, F.T. AU - Dijkhuizen, M.A. AU - West, C.E. AU - Ven-Jongekrijg, J. van der AU - Muhilal AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/13803 PB - Nature publishing group TI - Reduced production of immunoregulatory cytokines in vitamin A- and zinc-deficient Indonesian infants - test EP - 1504 SN - 0954-3007 IS - iss. 11 SP - 1498 JF - European Journal of Clinical Nutrition VL - vol. 58 ER - TY - JOUR AU - Netea, M.G. AU - Kullberg, B.J. AU - Jong, D.J. de AU - Franke, B. AU - Sprong, T. AU - Naber, T.H.J. AU - Drenth, J.P.H. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/13836 PB - Wiley-v c h verlag gmbh TI - NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease EP - 2059 SN - 0014-2980 IS - iss. 7 SP - 2052 JF - European Journal of Immunology VL - vol. 34 ER - TY - JOUR AU - Sprong, T. AU - Moller, A.S.W. AU - Bjerre, A. AU - Wedege, E. AU - Kierulf, P. AU - Meer, J.W.M. van der AU - Brandtzaeg, P. AU - Deuren, M. van AU - Mollnes, T.E. PY - 2004 UR - https://hdl.handle.net/2066/13817 PB - Amer soc microbiology TI - Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide EP - 3349 SN - 0019-9567 IS - iss. 6 SP - 3344 JF - Infection and Immunity VL - vol. 72 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/13817/13817.pdf?sequence=1 ER - TY - JOUR AU - Drewe, E. AU - Meer, J.W.M. van der AU - Powell, R.J. AU - Kelley, R.I. AU - Stalenhoef, A.F.H. AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/13820 PB - Mosby, inc TI - Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome EP - 483 SN - 0009-9236 IS - iss. 5 SP - 476 JF - Clinical Pharmacology and Therapeutics VL - vol. 75 ER - TY - JOUR AU - Vogtlander, N.P.J. AU - Kasteren, M.E.E. van AU - Natsch, S. AU - Kullberg, B.J. AU - Hekster, Y.A. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/13809 PB - Amer medical assoc TI - Improving the process of antibiotic therapy in daily practice - Interventions to optimize timing, dosage adjustment to renal function, and switch therapy EP - 1212 SN - 0003-9926 IS - iss. 11 SP - 1206 JF - Archives of Internal Medicine VL - vol. 164 ER - TY - JOUR AU - Netea, M.G. AU - Kullberg, B.J. AU - Jacobs, L.E.H. AU - Verver-Jansen, T.J.G. AU - Ven-Jongekrijg, J. van der AU - Galama, J.M.D. AU - Stalenhoef, A.F.H. AU - Dinarello, C.A. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/13835 PB - Amer assoc immunologists TI - Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release EP - 1482 SN - 0022-1767 IS - iss. 2 SP - 1477 JF - Journal of Immunology VL - vol. 173 ER - TY - JOUR AU - Lange, F.P. de AU - Kalkman, J.S. AU - Bleijenberg, G. AU - Hagoort, P. AU - Werf, S.P. van der AU - Meer, J.W.M. van der AU - Toni, I. PY - 2004 UR - https://hdl.handle.net/2066/58757 AB - Chronic fatigue syndrome (CFS) is characterized by a debilitating fatigue of unknown aetiology. Patients who suffer from CFS report a variety of physical complaints as well as neuropsychological complaints. Therefore, it is conceivable that the CNS plays a role in the pathophysiology of CFS. The purpose of this study was to investigate neural correlates of CFS, and specifically whether there exists a linkage between disturbances in the motor system and CFS. We measured behavioural performance and cerebral activity using rapid event-related functional MRI in 16 CFS patients and 16 matched healthy controls while they were engaged in a motor imagery task and a control visual imagery task. CFS patients were considerably slower on performance of both tasks, but the increase in reaction time with increasing task load was similar between the groups. Both groups used largely overlapping neural resources. However, during the motor imagery task, CFS patients evoked stronger responses in visually related structures. Furthermore, there was a marked between-groups difference during erroneous performance. In both groups, dorsal anterior cingulate cortex was specifically activated during error trials. Conversely, ventral anterior cingulate cortex was active when healthy controls made an error, but remained inactive when CFS patients made an error. Our results support the notion that CFS may be associated with dysfunctional motor planning. Furthermore, the between-groups differences observed during erroneous performance point to motivational disturbances as a crucial component of CFS. TI - Neural correlates of the chronic fatigue syndrome - an fMRI study EP - 1957 SN - 0006-8950 IS - iss. Pt 9 SP - 1948 JF - Brain VL - vol. 127 DO - http://dx.doi.org/10.1093/brain/awh225 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/58757/58757.pdf?sequence=1 ER - TY - JOUR AU - Netea, M.G. AU - Kullberg, B.J. AU - Jacobs, L.E. AU - Verver-Jansen, T.J.G. AU - Ven-Jongekrijg, J. van der AU - Galama, J.M.D. AU - Stalenhoef, A.F.H. AU - Dinarello, C.A. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/59039 AB - Recent studies suggest that inflammation plays a central role in the pathogenesis of atherosclerosis, and IFN-gamma is a prominent proinflammatory mediator in this context. However, it is unclear what stimuli are responsible for initial stimulation of IFN-gamma synthesis in the vessel wall. In the present study, we demonstrate that Chlamydia pneumoniae is an important stimulus for IFN-gamma synthesis, and this production depends on release of endogenous IL-18, IL-12, and IL-1, but not of TNF. The production of the proinflammatory cytokines TNF and IL-1beta from PBMC by sonicated C. pneumoniae was mediated through TLR2-dependent pathways. In contrast, C. pneumoniae stimulated the production of IL-18 through MyD88-dependent, TLR2-, TLR4-, and CD14-independent pathways, mediated by posttranscriptional mechanisms not involving de novo protein synthesis. In conclusion, C. pneumoniae is a potent stimulus of IFN-gamma production, in addition to the proinflammatory cytokines TNF and IL-1beta, which may contribute to its proatherogenic effects. Most interestingly, C. pneumoniae is also a potent inducer of IL-18 production through pathways independent of TLR2 and TLR4. TI - Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. EP - 1482 SN - 0022-1767 IS - iss. 2 SP - 1477 JF - Journal of Immunology VL - vol. 173 DO - http://dx.doi.org/10.4049/jimmunol.173.2.1477 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/59039/59039.pdf?sequence=1 ER - TY - JOUR AU - Netea, M.G. AU - Sutmuller, R.P.M. AU - Hermann, C. AU - Smits-van der Graaf, C.A.A. AU - Meer, J.W.M. van der AU - Krieken, J.H.J.M. van AU - Hartung, T. AU - Adema, G.J. AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/59239 AB - Toll-like receptor (TLR) 2 and TLR4 play a pivotal role in recognition of Candida albicans. We demonstrate that TLR2(-/-) mice are more resistant to disseminated Candida infection, and this is associated with increased chemotaxis and enhanced candidacidal capacity of TLR2(-/-) macrophages. Although production of the proinflammatory cytokines TNF, IL-1alpha, and IL-1beta is normal, IL-10 release is severely impaired in the TLR2(-/-) mice. This is accompanied by a 50% decrease in the CD4+CD25+ regulatory T (Treg) cell population in TLR2(-/-) mice. In vitro studies confirmed that enhanced survival of Treg cells was induced by TLR2 agonists. The deleterious role of Treg cells on the innate immune response during disseminated candidiasis was underscored by the improved resistance to this infection after depletion of Treg cells. In conclusion, C. albicans induces immunosuppression through TLR2-derived signals that mediate increased IL-10 production and survival of Treg cells. This represents a novel mechanism in the pathogenesis of fungal infections. TI - Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. EP - 3718 SN - 0022-1767 IS - iss. 6 SP - 3712 JF - Journal of Immunology VL - vol. 172 DO - http://dx.doi.org/10.4049/jimmunol.172.6.3712 ER - TY - JOUR AU - Meer, J.W.M. van der AU - Lamberts, S.W.J. AU - Buchwald, D. PY - 2004 UR - https://hdl.handle.net/2066/57829 TI - Dr Baschetti rides/writes again. EP - 317 SN - 0014-2972 IS - iss. 4 SP - 317 JF - European Journal of Clinical Investigation VL - vol. 34 DO - http://dx.doi.org/10.1111/j.1365-2362.2004.01328.x ER - TY - JOUR AU - Sprong, T. AU - Netea, M.G. AU - Ley, P. van der AU - Verver-Jansen, T.J.G. AU - Jacobs, L.E. AU - Stalenhoef, A.F.H. AU - Meer, J.W.M. van der AU - Deuren, M. van PY - 2004 UR - https://hdl.handle.net/2066/58282 AB - The use of lipoproteins has been suggested as a treatment for Gram-negative sepsis because they inhibit lipopolysaccharide (LPS)-mediated cytokine production. However, little is known about the neutralizing effects of lipoproteins on cytokine production by meningococcal LPS or whole Gram-negative bacteria. We assessed the neutralizing effect of LDLs, HDLs, and VLDLs on LPS- or whole bacteria-induced cytokines in human mononuclear cells. A strong inhibition of Escherichia coli LPS-induced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, and IL-10 by LDL and HDL was seen, whereas VLDL had a less pronounced effect. In contrast, Neisseria meningitidis LPS, in similar concentrations, was neutralized much less effectively than E. coli LPS. Effective neutralization of meningococcal LPS required a longer interaction time, a lower concentration of LPS, or higher concentrations of lipoproteins. The difference in neutralization was independent of the saccharide tail, suggesting that the lipid A moiety accounted for the difference. Minimal neutralizing effects of the lipoproteins were observed on whole E. coli or N. meningitidis bacteria under all conditions tested. These results indicate that efficient neutralization of LPS depends on the type of LPS, but a sufficiently long interaction time, a low LPS concentration, or high lipoprotein concentration also inhibited cytokines by the less efficiently neutralized N. meningitidis LPS. Irrespective of these differences, whole bacteria showed no neutralization by lipoproteins. TI - Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria. EP - 749 SN - 0022-2275 IS - iss. 4 SP - 742 JF - Journal of Lipid Research (Online) VL - vol. 45 DO - http://dx.doi.org/10.1194/jlr.M300453-JLR200 ER - TY - JOUR AU - Meijer, K. AU - Haagsma, E.B. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/57446 TI - A randomized, double-blind, placebo-controlled clinical trial of high-dose interferon-alpha induction treatment combined with ribavirin for chronic hepatitis C in hemophilia. EP - 196 SN - 1538-7933 IS - iss. 1 SP - 194 JF - Journal of Thrombosis and Haemostasis VL - vol. 2 DO - http://dx.doi.org/10.1111/j.1538-7836.2004.0562c.x ER - TY - JOUR AU - Sprong, T. AU - Jack, D.L. AU - Klein, N.J. AU - Turner, M.W. AU - Ley, P. van der AU - Steeghs, L. AU - Jacobs, L. AU - Meer, J.W.M. van der AU - Deuren, M. van PY - 2004 UR - https://hdl.handle.net/2066/57232 AB - Mannose binding lectin (MBL) is a key molecule in the lectin pathway of complement activation, and likely of importance in our innate defence against meningococcal infection. We evaluated the role of MBL in cytokine induction by LPS or non-LPS components of Neisseria meningitidis, using a meningococcal mutant deficient for LPS. Binding experiments showed that MBL exhibited low, but significant binding to encapsulated LPS+ meningococci (H44/76) and LPS-deficient (LPS-) meningococci (H44/76lpxA). Experiments with human mononuclear cells (PBMCs) showed that MBL significantly augmented IL-1beta production after stimulation with LPS+ and LPS- meningococci, in a dose-dependent fashion. In addition, IL-10 production was enhanced after stimulation with LPS- meningococci. In contrast, TNFalpha, IL-6 and IFNgamma productions were unaffected. No effect of MBL was observed on cytokine induction by meningococcal LPS. MBL enhanced cytokine production at concentrations >10(7) meningococci. It is concluded that MBL interacts with non-LPS components of N. meningitidis and in this way modulates the cytokine response. TI - Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis. EP - 66 SN - 1043-4666 IS - iss. 2 SP - 59 JF - Cytokine VL - vol. 28 DO - https://doi.org/10.1016/j.cyto.2004.06.007 ER - TY - JOUR AU - Simon, A. AU - Drewe, E. AU - Meer, J.W.M. van der AU - Powell, R.J. AU - Kelley, R.I. AU - Stalenhoef, A.F.H. AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/57893 AB - Hyperimmunoglobulinemia D (hyper-IgD) and periodic fever syndrome, a hereditary autoinflammatory syndrome, is characterized by lifelong recurrent episodes of fever and inflammation. No effective treatment is known. It is caused by a defect of mevalonate kinase, an enzyme that follows 3'-hydroxy-3'-methylglutaryl-coenzyme A (HMG-CoA) reductase in the isoprenoid pathway. We wanted to test the hypothesis that inhibition of HMG-CoA reductase would ameliorate the inflammatory attacks. Six patients with hyper-IgD syndrome and proven mevalonate kinase deficiency were followed up for 2 treatment periods with either simvastatin, 80 mg/d, or placebo for 24 weeks, separated by a 4-week washout period in a double-blind fashion. Simvastatin resulted in a drop in urinary mevalonic acid concentration in all patients and decreased the number of febrile days in 5 of 6 patients. No side effects were observed. These data offer preliminary evidence for the hypothesis that simvastatin may improve inflammatory attacks in the hyper-IgD syndrome. This highlights the anti-inflammatory properties of HMG-CoA reductase inhibition. TI - Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. EP - 483 SN - 0009-9236 IS - iss. 5 SP - 476 JF - Clinical Pharmacology and Therapeutics VL - vol. 75 DO - https://doi.org/10.1016/j.clpt.2004.01.012 ER - TY - JOUR AU - Simon, A. AU - Bijzet, J. AU - Voorbij, H.A. AU - Mantovani, A. AU - Meer, J.W.M. van der AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/58612 AB - BACKGROUND: Classical type hyper-immunoglobulin D (IgD) syndrome (HIDS) is an hereditary auto-inflammatory disorder, characterized by recurrent episodes of fever, lymphadenopathy, abdominal distress and a high serum concentration of IgD. It is caused by mevalonate kinase deficiency. OBJECTIVE: To further characterize the acute phase response during fever attacks in HIDS in order to improve diagnosis. SUBJECTS: Twenty-two mevalonate kinase-deficient HIDS patients. METHODS: Blood samples were drawn during and in between febrile attacks, and concentrations ofC-reactive protein (CRP), ferritin, procalcitonin, pentraxin 3, IgD and cholesterol in several lipoprotein fractions were determined. RESULTS: The marked acute phase response at the time of a fever attack in classical type HIDS is reflected by a rise in CRP accompanied by a moderate but statistically significant rise in procalcitonin and pentraxin 3. In only two of 22 patients, procalcitonin concentration rose above 2 ng mL(-1) during fever attack, compatible with the noninfectious nature of these attacks. Ferritin does not reach the high concentrations found in adult-onset Still's disease. Despite the defect in mevalonate kinase, a component of cholesterol metabolism, serum cholesterol did not change during attacks. IgD concentration is elevated regardless of disease activity, although there is appreciable variation during life. Its role in HIDS remains unclear. CONCLUSION: The combination of high CRP concentration plus procalcitonin concentration <2 ng mL(-1) in a symptomatic HIDS patient might indicate a febrile attack without (bacterial) infection; this observation warrants further investigation for its usefulness as a marker in clinical practice. TI - Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response. EP - 253 SN - 0954-6820 IS - iss. 3 SP - 247 JF - Journal of Internal Medicine VL - vol. 256 DO - https://doi.org/10.1111/j.1365-2796.2004.01359.x ER - TY - JOUR AU - Sprong, T. AU - Moller, A.S. AU - Bjerre, A. AU - Wedege, E. AU - Kierulf, P. AU - Meer, J.W.M. van der AU - Brandtzaeg, P. AU - Deuren, M. van AU - Mollnes, T.E. PY - 2004 UR - https://hdl.handle.net/2066/58036 AB - Fulminant meningococcal sepsis has been termed the prototypical lipopolysaccharide (LPS)-mediated gram-negative septic shock. Systemic inflammation by activated complement and cytokines is important in the pathogenesis of this disease. We investigated the involvement of meningococcal LPS in complement activation, complement-dependent inflammatory effects, and cytokine or chemokine production. Whole blood anticoagulated with lepirudin was stimulated with wild-type Neisseria meningitidis H44/76 (LPS+), LPS-deficient N. meningitidis H44/76lpxA (LPS-), or purified meningococcal LPS (NmLPS) at concentrations that were relevant to meningococcal sepsis. Complement activation products, chemokines, and cytokines were measured by enzyme-linked immunosorbent assays, and granulocyte CR3 (CD11b/CD18) upregulation and oxidative burst were measured by flow cytometry. The LPS+ and LPS- N. meningitidis strains both activated complement effectively and to comparable extents. Purified NmLPS, used at a concentration matched to the amount present in whole bacteria, did not induce any complement activation. Both CR3 upregulation and oxidative burst were also induced, independent of LPS. Interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and macrophage inflammatory protein 1alpha production was predominantly dependent on LPS, in contrast to IL-8 production, which was also markedly induced by the LPS- meningococci. In this whole blood model of meningococcal sepsis, complement activation and the immediate complement-dependent inflammatory effects of CR3 upregulation and oxidative burst occurred independent of LPS. TI - Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide. EP - 3349 SN - 0019-9567 IS - iss. 6 SP - 3344 JF - Infection and Immunity VL - vol. 72 DO - https://doi.org/10.1128/IAI.72.6.3344-3349.2004 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/58036/58036.pdf?sequence=1 ER - TY - JOUR AU - Prins, J.B. AU - Bos, E. AU - Huibers, M.J.H. AU - Servaes, P. AU - Werf, S.P. van der AU - Meer, J.W.M. van der AU - Bleijenberg, G. PY - 2004 UR - https://hdl.handle.net/2066/57919 AB - BACKGROUND: Several studies suggested that the surroundings of chronic fatigue syndrome (CFS) patients are of importance in the persistence of complaints. Contrary to what was expected, participation in support groups has not led to clinical improvement. The purpose of the present study was to describe social support in CFS patients as compared with other fatigued and non-fatigued groups. Further, changes in social support and the influence of social support on the course of CFS over a period of more than 1 year were studied in patients with and without treatment. METHODS: Baseline data were assessed in 270 CFS patients, 150 disease-free breast cancer patients, 151 fatigued employees on sick-leave and 108 healthy subjects using the Social Support List and Significant Others Scale. CFS patients were followed in cognitive behaviour therapy (CBT), guided support groups and natural course at 8 and 14 months. RESULTS: CFS patients and fatigued employees reported more negative interactions and insufficiency of supporting interactions than cancer patients and healthy controls. No differences in frequency of supporting interactions were found. Negative interactions decreased significantly after treatment with CBT, but did not change in support groups or natural course. In the natural course, higher fatigue severity at 8 months was predicted by more negative interactions at baseline. CONCLUSIONS: In CFS patients and fatigued employees, social support is worse than in disease-free cancer patients and healthy controls. Lack of social support was identified as a new factor in the model of perpetuating factors of fatigue severity and functional impairment in CFS. TI - Social support and the persistence of complaints in chronic fatigue syndrome. EP - 182 SN - 0033-3190 IS - iss. 3 SP - 174 JF - Psychotherapy and Psychosomatics VL - vol. 73 DO - https://doi.org/10.1159/000076455 ER - TY - JOUR AU - Simon, A. AU - Bodar, E.J. AU - Hilst, J.C.H. van der AU - Meer, J.W.M. van der AU - Fiselier, T.J.W. AU - Cuppen, M.P. AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/58069 TI - Beneficial response to interleukin 1 receptor antagonist in traps. EP - 210 SN - 0002-9343 IS - iss. 3 SP - 208 JF - American Journal of Medicine VL - vol. 117 ER - TY - JOUR AU - Netea, M.G. AU - Hijmans, A.G.M. AU - Wissen, S. van AU - Smilde, T.J. AU - Trip, M.D. AU - Kullberg, B.J. AU - Boo, T.M. de AU - Meer, J.W.M. van der AU - Kastelein, J.J.P. AU - Stalenhoef, A.F.H. PY - 2004 UR - https://hdl.handle.net/2066/59240 AB - BACKGROUND: Toll-like receptor-4 (TLR4) is a major receptor for inflammatory stimuli potentially involved in the pathogenesis of atherosclerosis, such as lipopolysaccharide (LPS) and heat-shock proteins. The Asp299Gly polymorphism of the TLR4 gene has been associated with a reduced intima-media thickness (IMT) of the common carotid artery in healthy individuals. We have investigated whether the presence of the Asp299Gly polymorphism in patients with familial hypercholesterolaemia (FH) has a similar protective effect, and whether it influences the effects of HMG-CoA reductase treatment. MATERIALS AND METHODS: A cohort of 293 FH patients and 200 healthy volunteers were genotyped for the presence of the Asp299Gly allele using polymerase chain reaction followed by restriction fragment length polymorphism analysis. Intima-media thickness measurements, inflammatory parameters and the effect of HMG-CoA reductase inhibitors were compared between the patients with and without Asp299Gly allele. RESULTS: The Asp299Gly allele was present in 10.6% of the FH patients and 11.0% of the healthy individuals. Whereas the FH patients carrying the Asp299Gly allele displayed a reduced absolute IMT value compared with the FH patients carrying the wild-type allelle, the difference did not reach statistical significance. In addition, the effect of treatment with HMG-CoA reductase inhibitors was not influenced by the presence of Asp299Gly allele. CONCLUSION: The presence of the Asp299Gly allele of the TLR4 gene does not seem to exert a major influence on the progression of atherosclerosis in patients with FH. TI - Toll-like receptor-r Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia. EP - 99 SN - 0014-2972 IS - iss. 2 SP - 94 JF - European Journal of Clinical Investigation VL - vol. 34 DO - https://doi.org/10.1111/j.1365-2362.2004.01303.x ER - TY - JOUR AU - Wieringa, F.T. AU - Dijkhuizen, M.A. AU - West, C.E. AU - Ven-Jongekrijg, J. van der AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/57747 AB - OBJECTIVE: To determine effects of vitamin A, zinc and iron deficiency in Indonesian infants on the ability to produce immunoregulatory cytokines. DESIGN, SETTING AND SUBJECTS: Immunological assessment was done in 59 infants participating in a cross-sectional nutritional survey in rural West Java, Indonesia. Production of T-helper cell type-1 (Th1, cell-mediated) cytokines interferon-gamma (IFN-gamma), interleukin-12 (IL-12), interleukin-18 (IL-18) and T-helper cell type-2 (Th2, humoral) cytokine interleukin-6 (IL-6) were measured after stimulation with lipopolysaccharide and phytohemagglutinin in an ex vivo whole blood culture system. Circulating neopterin concentrations were determined as an indicator of in vivo macrophage activity. RESULTS: Of the infants, 48% were vitamin A deficient, 44% were anemic (with 17% having iron deficiency anemia), and 17% were zinc deficient. Vitamin-A deficient infants had significantly reduced ex vivo production of IFN-gamma, but also significantly higher circulating neopterin concentrations. Production of IFN-gamma and IL-12 were strongly correlated, IFN-gamma and IL-18 production were not. Zinc deficiency was accompanied by significantly reduced white blood cell counts and reduced ex vivo production of IL-6. Iron status was not related to cytokine production. CONCLUSIONS: This study shows that in vitamin A deficiency there is Th1 dominance in a steady state, combined however with impairment of the Th1 response after stimulation, whereas in zinc deficiency, there is a decreased Th2 response. Overall, vitamin A deficiency and zinc deficiency have marked albeit different effects on the immunocompetence of infants, affecting both cell-mediated and humoral components of the immune system. TI - Reduced production of immunoregulatory cytokines in vitamin A- and zinc-deficient Indonesian infants. EP - 1504 SN - 0954-3007 IS - iss. 11 SP - 1498 JF - European Journal of Clinical Nutrition VL - vol. 58 DO - https://doi.org/10.1038/sj.ejcn.1601998 ER - TY - JOUR AU - Popa, C. AU - Netea, M.G. AU - Radstake, T.R.D.J. AU - Meer, J.W.M. van der AU - Stalenhoef, A.F.H. AU - Riel, P.L.C.M. van AU - Barrera Rico, P. PY - 2004 UR - https://hdl.handle.net/2066/58079 AB - BACKGROUND: Tumour necrosis factor (TNF) is known to increase the concentrations of interleukin (IL) 6 and C reactive protein (CRP) and to induce proatherogenic changes in the lipid profile and may increase the cardiovascular risk of patients with rheumatoid arthritis (RA) and other inflammatory disorders. OBJECTIVE: To assess whether anti-TNF therapy modifies the cardiovascular risk profile in patients with RA. METHODS: The lipoprotein spectrum and the inflammation markers CRP and IL6 were investigated in 33 patients with RA treated with human anti-TNF monoclonal antibodies (D2E7, adalimumab, Humira) and 13 patients with RA given placebo, before and after 2 weeks' treatment. RESULTS: In the anti-TNF treated group, the mean (SD) concentrations of HDL-cholesterol were significantly higher after 2 weeks' treatment (0.86 (0.30) mmol/l v 0.98 (0.33) mmol/l, p<0.01), whereas LDL and triglyceride levels were not significantly changed. Additionally, a significant decrease in CRP (86.1 (54.4) mg/l v 35.4 (35.0) mg/l, p<0.0001), and IL6 (88.3 (60.5) pg/ml v 42.3 (40.7) pg/ml, p<0.001) concentrations was seen in this group. No changes in lipid profile, IL6, or CRP levels were seen in the placebo group. CONCLUSIONS: TNF neutralisation with monoclonal anti-TNF antibodies increased HDL-cholesterol levels and decreased CRP and IL6 levels after 2 weeks. Therefore this treatment may improve the cardiovascular risk profile of patients with RA. TI - Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis. EP - 305 SN - 0003-4967 IS - iss. 2 SP - 303 JF - Annals of the Rheumatic Diseases VL - vol. 64 ER - TY - JOUR AU - Bleijenberg, G. AU - Vercoulen, J.H.M.M. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/57510 TI - Reply to: Chronic fatigue syndrome: a clinical and laboratory study with a well-matched control group - How important are symptom criteria in the definition of CFS? EP - 269 SN - 0954-6820 IS - iss. 3 SP - 268 JF - Journal of Internal Medicine VL - vol. 256 DO - https://doi.org/10.1111/j.1365-2796.2004.01379.x ER - TY - JOUR AU - Bleijenberg, G. AU - Vercoulen, J.H.M.M. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/58272 TI - How important are symptom criteria in the definition of CFS? EP - 269 SN - 0954-6820 IS - iss. 3 SP - 268 JF - Journal of Internal Medicine VL - vol. 256 DO - https://doi.org/10.1111/j.1365-2796.2004.01379.x ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Corstens, F.H.M. AU - Meer, J.W.M. van der AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/58473 TI - Fever of unknown origin: prospective comparison of diagnostic value of (18)F-FDG PET and (111)In-granulocyte scintigraphy. EP - 1344 SN - 1619-7070 IS - iss. 9 SP - 1342 JF - European Journal of Nuclear Medicine and Molecular Imaging VL - vol. 31 DO - https://doi.org/10.1007/s00259-004-1634-6 ER - TY - JOUR AU - VogtlÃĪnder, N.P.J. AU - Kasteren, M.E.E. van AU - Natsch, S.S. AU - Kullberg, B.J. AU - Hekster, Y.A. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/58146 AB - BACKGROUND: Timely administration of the first dose, dosage adjustment to renal function, switch from intravenous to oral administration, and streamlining are important aspects of rational antibiotic prescription. The goals of this study were to investigate all of these variables, compare them with predefined quality standards, and implement improvement with specific interventions. METHODS: At the departments of internal medicine, surgery, and neurology and the emergency department of a tertiary referral university medical center, all consecutive patients receiving therapeutic antibiotics were enrolled. Dosages, timing of first doses, dosing intervals, administration routes, and adjustment of the chosen drug to clinical data were investigated. After the preintervention period, barriers to change were identified, followed by specific interventions and a postintervention measurement. RESULTS: In the preintervention and postintervention periods, 247 and 250 patients were enrolled, receiving 563 and 598 antibiotic prescriptions, respectively. The mean time from the order to first dose at the wards improved from 2.7 to 1.7 hours in potentially severe cases (P =.003). Dosage adjustment to renal function remained unchanged at 45% vs 52% (P =.09) of cases where necessary. Switching of therapy from intravenous to oral improved from 46% to 62% (P =.03) and was performed a mean of 1.6 days earlier (P =.002). Streamlining was performed correctly in most cases, and thus no interventions were necessary. CONCLUSIONS: Timing of antibiotic therapy and switch therapy may be improved with a combination of interventions. To improve poor adjustment of dosing to renal function, other strategies are needed. In our setting, streamlining was already correct in most cases. TI - Improving the process of antibiotic therapy in daily practice: interventions to optimize timing, dosage adjustment to renal function, and switch therapy. EP - 1212 SN - 0003-9926 IS - iss. 11 SP - 1206 JF - Archives of Internal Medicine VL - vol. 164 DO - https://doi.org/10.1001/archinte.164.11.1206 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Bredie, S.J.H. AU - Meer, J.W.M. van der AU - Corstens, F.H.M. AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/58426 TI - Fluorine 18 fluorodeoxyglucose positron emission tomography in the diagnosis and follow-up of three patients with vasculitis. EP - 53 SN - 0002-9343 IS - iss. 1 SP - 50 JF - American Journal of Medicine VL - vol. 116 ER - TY - JOUR AU - Netea, M.G. AU - Smits-van der Graaf, C.A.A. AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/57770 AB - Toll-like receptors (TLRs) have been identified as a major class of pattern-recognition receptors. Recognition of pathogen-associated molecular patterns by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces signals responsible for the activation of the innate immune response. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans. Through the study of fungal infection in knock-out mice deficient in either TLRs or TLR-associated adaptor molecules, it became apparent that specific TLRs such as TLR2 and TLR4 play differential roles in the activation of the various arms of the innate immune response. Recent data also suggest that TLRs offer escape mechanisms to certain pathogenic microorganisms, especially through TLR2-driven induction of anti-inflammatory cytokines. These new data have substantially increased our knowledge of the recognition of fungal pathogens, and the study of TLRs remains one of the most active areas of research in the field of fungal infections. TI - Recognition of fungal pathogens by Toll-like receptors. EP - 676 SN - 0934-9723 IS - iss. 9 SP - 672 JF - European Journal of Clinical Microbiology and Infectious Diseases VL - vol. 23 DO - https://doi.org/10.1007/s10096-004-1192-7 ER - TY - JOUR AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/58893 TI - [Retention period for patient data: the health council of the Netherlands pleads for a change in the law] J2 - Retention period for patient data: the health council of the Netherlands pleads for a change in the law EP - 1747 SN - 0028-2162 IS - iss. 25 SP - 1265 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 148 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Jager, G.J. AU - Tack, C.J.J. AU - Meer, J.W.M. van der AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/58510 AB - Pylephlebitis or septic thrombophlebitis of the portal vein is a serious infectious disorder. Early diagnosis is difficult, due to nonspecific symptoms and signs, limitations of diagnostic modalities and the lack of familiarity of physicians with this entity. We report the history of a 73-year-old man with fever of unknown origin (FUO) in whom laboratory tests, blood and urine cultures, chest X-ray, abdominal ultrasound, and Indium-111-leucocyte scintigraphy did not reveal the cause of the fever. F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) subsequently pointed to the diagnosis of pylephlebitis, which was confirmed by computed tomography (CT) and percutaneous puncture. We conclude that FDG PET allows detecting inflammatory foci in patients with FUO and offers to make the diagnosis of pylephlebitis at an early stage. TI - F-18-fluorodeoxyglucose positron emission tomography leading to a diagnosis of septic thrombophlebitis of the portal vein: description of a case history and review of the literature. EP - 423 SN - 0954-6820 IS - iss. 3 SP - 419 JF - Journal of Internal Medicine VL - vol. 255 DO - https://doi.org/10.1046/j.1365-2796.2003.01259.x ER - TY - JOUR AU - Simon, A. AU - Kremer, H.P.H. AU - Wevers, R.A. AU - Scheffer, H. AU - Jong, J.G.N. de AU - Meer, J.W.M. van der AU - Drenth, J.P.H. PY - 2004 UR - https://hdl.handle.net/2066/57313 AB - Both mevalonic aciduria, characterized by psychomotor retardation, cerebellar ataxia, recurrent fever attacks, and death in early childhood, and hyper-immunoglobulin D (hyper-IgD) syndrome, with recurrent fever attacks without neurologic symptoms, are caused by a functional deficiency of mevalonate kinase. In a systematic review of known mevalonate kinase-deficient patients, the authors identified five adults with phenotypic overlap between these two syndromes, which argues for a continuous spectrum of disease. Mevalonate kinase deficiency should be considered in adult patients with fitting neurologic symptoms, with or without periodic fever attacks. TI - Mevalonate kinase deficiency: Evidence for a phenotypic continuum. EP - 997 SN - 0028-3878 IS - iss. 6 SP - 994 JF - Neurology VL - vol. 62 DO - https://doi.org/10.1212/01.WNL.0000115390.33405.F7 ER - TY - JOUR AU - Stuyt, P.M.J. AU - Graaf, J. de AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/59054 AB - Internal medicine is a broad medical speciality and choosing the residency programme opens up a variety of career tracks. Despite this broad choice of subspecialities, we found that within our residency programme for internal medicine in the Nijmegen region between 1981 and 2000, 29% of the residents did not become internists but switched to other medical specialities. To further complicate the efficiency of the residency programme, about 20% of the residents who became internists did not finish within six years, but had a delay of two years due to combined internal medicine/PhD tracks (the training for internist/clinical investigator). In another 20% there is a delay of six to 12 months due to part-time training tracks as well as to (multiple) pregnancies of female residents and parental leave of both sexes. Our data imply that nationwide data are urgently needed to re-evaluate the manpower planning for internal medicine by taking into consideration not only the number of residents starting in the residency programme but also to include the number of residents who actually do become internists. TI - Who does become an internist? EP - 101 SN - 0300-2977 IS - iss. 3 SP - 98 JF - Netherlands Journal of Medicine VL - vol. 62 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/59054/59054.pdf?sequence=1 ER - TY - JOUR AU - Volman, T.J.H. AU - Goris, R.J.A. AU - Meer, J.W.M. van der AU - Hendriks, T. PY - 2004 UR - https://hdl.handle.net/2066/59237 AB - OBJECTIVE: We sought to quantitate the course of specific cytokine mRNA expression in tissues that exhibit increasing histopathological changes in time in an animal model for the multiple organ dysfunction syndrome (MODS). SUMMARY BACKGROUND DATA: The development of treatment protocols for MODS requires elucidation of the mechanisms and mediators involved. To devise logical interventions, it is necessary to collect data on cytokine expression at tissue level during the development of MODS. METHODS: Ninety-four C57BL/6 mice were given an intraperitoneal injection of 40 microg of lipopolysaccharide (LPS), followed by zymosan at a dose of 0.8 mg/g body weight 6 days later (day 0). Six additional animals did not receive zymosan and acted as controls. At several time points after zymosan injection, 6 randomly assigned, zymosan-treated animals were killed, and their livers, lungs, spleens, and kidneys were collected. mRNA expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, macrophage migration inhibiting factor, IL-12, interferon-gamma, and IL-10 was measured using a real-time reverse transcription-polymerase chain reaction assay. RESULTS: The injection of zymosan induced an acute peritonitis, followed by an apparent recovery. From approximately day 6 onwards, animals started to display MODS-like symptoms. During the peritonitis phase, up-regulation of cytokine mRNA was limited. During the period of apparent recovery, cytokine mRNA expression strongly increased, mostly reaching its maximum at day 9 when deterioration of the clinical condition had already set in. The up-regulation of tumor necrosis factor-alpha mRNA was most pronounced, especially in the lungs and liver. CONCLUSIONS: Interventions should preferentially be targeted against multiple cytokines and, at least in this model, there may be a treatment window well after the initial challenge. TI - Tissue- and time-dependent upregulation of cytokine mRNA in a murine model for the multiple organ dysfunction syndrome. EP - 150 SN - 0003-4932 IS - iss. 1 SP - 142 JF - Annals of Surgery VL - vol. 240 DO - https://doi.org/10.1097/01.sla.0000130725.52373.e7 ER - TY - JOUR AU - Netea, M.G. AU - Smits-van der Graaf, C.A.A. AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/59241 AB - Toll-like receptors (TLRs) have been identified as a major class of pattern-recognition receptors. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, alone or in heterodimerization with other TLR or non-TLR receptors, induces signals responsible for the activation of genes important for an effective host defense, especially proinflammatory cytokines. Although a certain degree of redundancy exists between signals induced by the various TLRs, recent studies have identified intracellular pathways specific for individual TLRs. This leads to the release of cytokine profiles specific for particular PAMPs, and thus, TLRs confer a certain degree of specificity to the innate-immune response. In addition to the activation of the innate-immune response, TLR-mediated recognition represents a link between the innate- and acquired-immune systems, by inducing the maturation of dendritic cells and directing the T helper responses. Alternatively, recent data have also suggested TLR-mediated escape mechanisms used by certain pathogenic microorganisms, especially through TLR2 induction of anti-inflammatory cytokines. Finally, the crucial role of TLRs for the host defense against infections has been strengthened recently by the description of patients partially defective in the TLR-activation pathways. TI - Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system. EP - 755 SN - 0741-5400 IS - iss. 5 SP - 749 JF - Journal of Leukocyte Biology VL - vol. 75 DO - https://doi.org/10.1189/jlb.1103543 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/59241/59241.pdf?sequence=1 ER - TY - JOUR AU - Netea, M.G. AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/59242 AB - Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory cytokines. Recent studies also suggest that pathogenic microorganisms can modulate or interfere with TLR-mediated pattern recognition and can use TLRs as an escape mechanism from the host defense. Three major TLR-mediated escape mechanisms have been identified: TLR2-induced immunosuppression, especially through induction of interleukin (IL)-10 release; blockade of TLR recognition; and TLR-mediated induction of viral replication. Thus, TLR signals are not only beneficial to the host, but in certain situations the activation of particular TLR responses by microorganisms might serve as an escape mechanism from the host defense. TI - Toll-like receptors as an escape mechanism from the host defense. EP - 488 SN - 0966-842X IS - iss. 11 SP - 484 JF - Trends in Microbiology VL - vol. 12 DO - https://doi.org/10.1016/j.tim.2004.09.004 ER - TY - JOUR AU - Locadia, M. AU - Bossuyt, P.M. AU - Stalmeier, P.F.M. AU - Sprangers, M.A.G. AU - Dongen, C.J. van AU - Middeldorp, S. AU - Bank, I. AU - Meer, J.W.M. van der AU - Hamulyak, K. AU - Prins, M.H. PY - 2004 UR - https://hdl.handle.net/2066/59176 AB - Determining the optimal duration of vitamin K antagonist (VKA) therapy for patients with venous thromboembolism (VTE) requires a weighting of the benefits and risks of treatment. The objectives of our study were to investigate patient variability in health state valuations associated with VKA therapy and treatment preferences, and to investigate the extent to which valuations and treatment preferences are associated with prior experience with these health states and other patient characteristics. Valuations of outcomes after VTE scaled from 0 (tantamount to death) to 1 (tantamount to perfect health) were elicited from 53 patients who had experienced VTE, 23 patients who had experienced major bleeding during treatment, and 48 patients with the post-thrombotic syndrome. In addition, patients' treatment preferences were evaluated using treatment trade-off questions. Median health state valuations ranged from 0.33 for 'non-fatal haemorrhagic stroke' to 0.96 for 'no VKA treatment'.Variability between patients was substantial. Patients' treatment preferences also varied: 25% of patients chose cessation of treatment, regardless of the probability of recurrent VTE presented, whereas 23% of patients were never willing to choose cessation of treatment. Differences in valuations and treatment preferences were not associated with type of event experienced. Due to the substantial and unpredictable variability in valuations and treatment preferences, recommendations regarding treatment duration should be tailored to patients' specific values and concerns. TI - Treatment of venous thromboembolism with vitamin K antagonists: patients' health state valuations and treatment preferences. EP - 1341 SN - 0340-6245 IS - iss. 6 SP - 1336 JF - Thrombosis and Haemostasis VL - vol. 92 DO - https://doi.org/10.1160/TH04-02-0075 ER - TY - JOUR AU - Stuyt, R.J.L. AU - Netea, M.G. AU - Krieken, J.H.J.M. van AU - Meer, J.W.M. van der AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/57772 AB - Endogenous interleukin (IL)-18 is necessary for host defense against candidiasis. Prophylactic treatment of Candida albicans-infected mice with recombinant murine (r) IL-18 decreased mortality, which was accompanied by a decreased outgrowth of yeasts in the kidneys 1 day after infection. Therapeutic administration of rIL-18 also resulted in decreased outgrowth of C. albicans in the kidneys and increased levels of interferon- gamma, both in the circulation and after in vitro stimulation of splenocytes with C. albicans. Histopathologic analysis of the kidneys showed increased inflammation and decreased growth of C. albicans in rIL-18-treated mice. In conclusion, rIL-18 improves outcome of disseminated candidiasis in mice and may prove useful as adjuvant immunotherapy of fungal infections. TI - Recombinant interleukin-18 protects against disseminated Candida albicans infection in mice. EP - 1527 SN - 0022-1899 IS - iss. 8 SP - 1524 JF - The Journal of Infectious Diseases VL - vol. 189 DO - https://doi.org/10.1086/382955 ER - TY - JOUR AU - Netea, M.G. AU - Brouwer, A.E. AU - Hoogendoorn, L. AU - Meer, J.W.M. van der AU - Koolen, M. AU - Verweij, P.E. AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/59191 AB - BACKGROUND: Although Cryptococcus neoformans is a fungal pathogen that causes human disease predominantly in the immunocompromised host, severe cryptococcal infections are occasionally encountered in apparently immunocompetent individuals. Activation of cellular immunity by proinflammatory cytokines plays a central role in anticryptococcal defense. METHODS: We describe 2 patients with severe cryptococcal meningitis who appeared to have idiopathic CD4 lymphopenia. For these patients and for 4 healthy volunteers, ex vivo stimulation of whole blood with microbial stimuli was used to investigate putative defects in cytokine production capacity. RESULTS: Assessment of the cytokine released from the 2 patients with CD4 lymphopenia revealed a defective production of the proinflammatory cytokines interferon (IFN)- gamma and tumor necrosis factor (TNF) but not of the anti-inflammatory cytokine interleukin-10 (IL-10). One patient with disease progression despite receipt of antifungal treatment was administered immunotherapy with recombinant IFN- gamma . Administration of recombinant IFN- gamma resulted in both restoration of immunological parameters and a sustained clinical recovery. CONCLUSIONS: Refractory meningitis may be due to defective TNF and IFN- gamma production, and IFN- gamma treatment may be useful in patients with an impaired cellular immune response and refractory cryptococcal meningitis. TI - Two patients with cryptococcal meningitis and idiopathic CD4 lymphopenia: defective cytokine production and reversal by recombinant interferon- gamma therapy. EP - 7 SN - 1058-4838 IS - iss. 9 SP - e83 JF - Clinical Infectious Diseases VL - vol. 39 DO - https://doi.org/10.1086/425121 ER - TY - JOUR AU - Severens, J.L. AU - Prins, J.B. AU - Wilt, G.J. van der AU - Meer, J.W.M. van der AU - Bleijenberg, G. PY - 2004 UR - https://hdl.handle.net/2066/57392 AB - BACKGROUND: There is some evidence that cognitive behaviour therapy (CBT) is efficacious in chronic fatigue syndrome (CFS), but little data on its cost-effectiveness. DESIGN: Prospective economic analysis alongside a randomized clinical trial. METHODS: CFS patients were randomly assigned to CBT, guided support groups (SG), or the 'natural course' (NC, no protocol-based interventions). Patients were treated for 8 months and followed-up for another 6 months. Costs per patient showing clinically significant improvement, based on the CIS fatigue scale, and costs per quality-adjusted life year, were determined for a time period of 14 months. RESULTS: Data were available for 171 patients at 8 months and for 128 at 14 months. At 8 and 14 months, the percentages of improved patients were 31% and 27% for CBT, 9% and 11% for SG, and 12% and 20% for NC. Mean QALYs gained at 14 months were, for CBT, SG and NC, respectively, 0.0737, -0.0018 and 0.0458. CBT and SG mean treatment costs were euro1490 and euro424. Other medical costs for CBT, SG, and NC, respectively, were euro324, euro623 and euro412 for the first period, and euro232, euro561 and euro378 for the second period. Non-medical costs for these periods for CBT, SG and NC were euro262, euro550, euro427 and euro226, euro439, euro287, respectively. Productivity costs were considerable, but not significantly different between groups. DISCUSSION: CBT was less costly and more effective than SG. Compared to NC, the baseline incremental cost-effectiveness of CBT was euro20 516 per CFS patient showing clinically significant improvement, and euro21 375 per QALY. The bootstrap ratios showed considerable uncertainty regarding the results. Future research should focus on productivity costs, and follow patients prospectively over a longer period. TI - Cost-effectiveness of cognitive behaviour therapy for patients with chronic fatigue syndrome. EP - 161 SN - 1460-2725 IS - iss. 3 SP - 153 JF - Quarterly Journal of Medicine VL - vol. 97 DO - https://doi.org/10.1093/qjmed/hch029 ER - TY - JOUR AU - Bleeker-Rovers, C.P. AU - Kleijn, E.M.H.A. de AU - Corstens, F.H.M. AU - Meer, J.W.M. van der AU - Oyen, W.J.G. PY - 2004 UR - https://hdl.handle.net/2066/57980 AB - Fever of unknown origin (FUO) and suspected focal infection or inflammation are challenging medical problems. The aim of this study was to assess the value of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) in patients with FUO and patients with suspected focal infection or inflammation. All FDG PET scans ordered because of FUO or suspected focal infection or inflammation in the last 4 years were reviewed. These results were compared with the final diagnosis. Thirty-five FDG PET scans were performed in 35 patients with FUO. A final diagnosis was established in 19 patients (54%). Of the total number of scans, 37% were clinically helpful. The positive predictive value of FDG PET in these patients was 87% and the negative predictive value was 95%. Fifty-five FDG PET scans were performed in 48 patients with suspected focal infection or inflammation. A final diagnosis was established in 38 patients (82%). Of the total number of scans, 65% were clinically helpful. The positive predictive value of FDG PET in these 55 episodes of suspected infection or inflammation was 95% and the negative predictive value was 100%. It is concluded that FDG PET appears to be a valuable imaging technique in the evaluation of FUO and suspected focal infection or inflammation. Furthermore, FDG PET could become a useful tool for evaluating the effect of treatment of infectious and inflammatory processes that cannot reliably be visualised by conventional techniques. However, to assess the additional diagnostic value of this technique, prospective studies of FDG PET as part of a structured diagnostic protocol are warranted. TI - Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation. EP - 37 SN - 1619-7070 IS - iss. 1 SP - 29 JF - European Journal of Nuclear Medicine and Molecular Imaging VL - vol. 31 DO - https://doi.org/10.1007/s00259-003-1338-3 ER - TY - JOUR AU - Crevel, R. van AU - Doorninck, D.J. van AU - Ams, J.E. van AU - Fat, H.T. AU - Vreden, S.G.S. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/58908 AB - OBJECTIVE: Evaluation of the extent and possible causes of the increased incidence of tuberculosis among Amazonian Indians in Surinam. DESIGN: Descriptive. METHOD: In two cross-sectional surveys in 1998 and 2000, the inhabitants of Kwamalasamutu, a village of Trio-Indians in Surinam, were examined for the presence of active and latent tuberculosis. Previous cases from the period 1995-2000 were evaluated retrospectively by consulting individual physicians and the archives of the 'Medische Zending' (Medical Mission), the 'Diakonessenhuis' hospital, the clinic for pulmonary diseases, and the Central Laboratory. Family ties and other factors that might be associated with tuberculosis were examined. Spoligotyping was done on all patient isolates. RESULTS: Between 1995 and 2000, active tuberculosis was diagnosed in 25 Indians from Kwamalasamutu, equal to 4.2 cases/1000 person-years (95% CI: 2.7-6.1). Tuberculin skin tests were positive in 105/733 Indians (14.3%). Cases of tuberculosis were found predominantly within certain families, who were genetically related. Spoligotyping of 5 Mycobacterium tuberculosis isolates from Trio-Indians showed unique patterns, which were also found in 34 isolates from elsewhere in Surinam. CONCLUSION: Tuberculosis was relatively common among Trio-Indians, clustering in certain families. This isolated tribe may have a genetic predisposition for tuberculosis, but their lifestyle and limited access to health care certainly play a role as well. TI - [Tuberculosis among Trio-Indians in Surinam] EP - 429 SN - 0028-2162 IS - iss. 9 SP - 425 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 148 ER - TY - JOUR AU - Netea, M.G. AU - Kullberg, B.J. AU - Jong, D.J. de AU - Franke, B. AU - Sprong, T. AU - Naber, A.H.J. AU - Drenth, J.P.H. AU - Meer, J.W.M. van der PY - 2004 UR - https://hdl.handle.net/2066/58732 AB - Mutations of the NOD2 gene have been associated with an increased susceptibility to Crohn's disease, but the pathogenetic mechanisms mediated by NOD2 remain elusive. In the present study, we demonstrate that the 3020insC frameshift-mutation in the NOD2 gene associated with Crohn's disease results in defective release of IL-10 from blood mononuclear cells after stimulation with the Toll-like receptor (TLR)2 ligands, peptidoglycan and Pam3Cys-KKKK, but not with bacterial LPS, a TLR4 ligand. The potential pathophysiological significance of this finding in patients with Crohn's disease and who are homozygous for this NOD2 mutation was substantiated by the finding of decreased anti-inflammatory cytokine release when cells from these patients were stimulated with different species of Bacteroides, an enteric microorganism implicated in the pathogenesis of Crohn's disease. In conclusion, defective NOD2 function results in a pro-inflammatory cytokine bias after stimulation of mononuclear cells with TLR2 stimuli, and this could contribute to the overwhelming inflammation seen in Crohn's disease. TI - NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. EP - 2059 SN - 0014-2980 IS - iss. 7 SP - 2052 JF - European Journal of Immunology VL - vol. 34 DO - https://doi.org/10.1002/eji.200425229 ER - TY - JOUR AU - Vonk, A.G. AU - Bont, N. de AU - Netea, M.G. AU - Demacker, P.N.M. AU - Meer, J.W.M. van der AU - Stalenhoef, A.F.H. AU - Kullberg, B.J. PY - 2004 UR - https://hdl.handle.net/2066/58198 AB - The effect of hyperlipoproteinemia on systemic candidiasis was investigated by assessing the susceptibility of hyperlipoproteinemic, apolipoprotein E (ApoE)-deficient (ApoE -/-) mice to a systemic Candida albicans infection. The absence of ApoE in these mice resulted in an eightfold increase in plasma lipoprotein concentrations in the very low-density lipoprotein (VLDL) fraction, as compared with levels seen in ApoE +/+ mice. Mortality due to candidemia was significantly higher (86%) in ApoE -/- mice than in ApoE+/+ mice (52%), and in platings of homogenized kidney material on fungal culture medium, ApoE -/- mice yielded significantly higher levels of C. albicans outgrowth than did ApoE+/+ mice. C albicans grew twofold better in ApoE -/- plasma in 4 h than in ApoE+/+ plasma, and depletion of lipoproteins from plasma resulted in a significant seven- to tenfold increase in C. albicans growth. Recombinant ApoE did not directly inhibit C. albicans growth. Our data indicate that the increased susceptibility of ApoE -/- mice to C albicans is due both to increased growth of blastoconidia in ApoE -/- mice in response to the availability of lipids as nutrients, and to the neutralization of candidacidal factors by lipoproteins. This study suggests that lipoproteins play a significant role in host defense against candidiasis. TI - Apolipoprotein-E-deficient mice exhibit an increased susceptibility to disseminated candidiasis. EP - 348 SN - 1369-3786 IS - iss. 4 SP - 341 JF - Medical Mycology VL - vol. 42 DO - https://doi.org/10.1080/13693780410001657135 ER -