TY  - JOUR
AU  - Netea, M.G.
AU  - Nold-Petry, C.A.
AU  - Nold, M.F.
AU  - Joosten, L.A.B.
AU  - Opitz, B.
AU  - Meer, J.H. van der
AU  - Veerdonk, F.L. van de
AU  - Ferwerda, G.
AU  - Heinhuis, S.M.
AU  - Devesa, I.
AU  - Funk, C.J.
AU  - Mason, R.J.
AU  - Kullberg, B.J.
AU  - Rubartelli, A.
AU  - Meer, J.W.M. van der
AU  - Dinarello, C.A.
PY  - 2009
UR  - https://hdl.handle.net/2066/80484
AB  - The processing of pro-interleukin-1beta depends on activation of caspase-1. Controversy has arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of interleukin-1beta (IL-1beta). Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from constitutively activated caspase-1 and release of endogenous adenosine triphosphate. The constitutive activation of caspase-1 depends on the inflammasome components, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and NALP3, but in monocytes caspase-1 activation is uncoupled from pathogen-associated molecular pattern recognition. In contrast, macrophages are unable to process and release IL-1beta solely by TLR ligands and require a second adenosine triphosphate stimulation. We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation.
TI  - Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
EP  - 2335
SN  - 0006-4971
IS  - iss. 10
SP  - 2324
JF  - Blood
VL  - vol. 113
DO  - https://doi.org/10.1182/blood-2008-03-146720
ER  - 
TY  - JOUR
AU  - Deuren, M. van
AU  - Ven-Jongekrijg, J. van der
AU  - Nier, E. van
AU  - Dalen, R. van
AU  - Pesman, G.J.
AU  - Bartelink, A.K.M.
AU  - Dinarello, C.A.
AU  - Meer, J.W.M. van der
PY  - 1997
UR  - https://hdl.handle.net/2066/25061
TI  - The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections
EP  - 1108
SN  - 0006-4971
IS  - iss. 3
SP  - 1101
JF  - Blood
VL  - vol. 90
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/25061/25061.PDF?sequence=1
ER  - 
TY  - JOUR
AU  - Deuren, M. van
AU  - Ven-Jongekrijg, J. van der
AU  - Nier, E. van
AU  - Dalen, R. van
AU  - Pesman, G.
AU  - Bartelink, A.K.M.
AU  - Dinarello, C.A.
AU  - Meer, J.W.M. van der
PY  - 1997
UR  - https://hdl.handle.net/2066/15123
TI  - The pattern of interleukin-1ß (IL-1ß) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections
EP  - 1108
SN  - 0006-4971
IS  - iss. 3
SP  - 1101
JF  - Blood
VL  - vol. 90
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/15123/4930.pdf?sequence=1
ER  -