TY  - JOUR
AU  - Damen, M.S.M.A.
AU  - Schraa, K.
AU  - Tweehuysen, L
AU  - Broeder, A.A. den
AU  - Netea, M.G.
AU  - Popa, C.
AU  - Joosten, L.A.B.
PY  - 2018
UR  - https://hdl.handle.net/2066/195853
TI  - Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients
SN  - 2045-2322
JF  - Scientific Reports
VL  - vol. 8
DO  - https://doi.org/10.1038/s41598-018-32485-0
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/195853/195853.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Damen, M.S.M.A.
AU  - Agca, R.
AU  - Holewijn, S.
AU  - Graaf, J. de
AU  - Santos, J.C. Dos
AU  - Riel, P.L.C.M. van
AU  - Fransen, J.
AU  - Coenen, M.J.H.
AU  - Nurmohamed, M.T.
AU  - Netea, M.G.
AU  - Dinarello, C.A.
AU  - Joosten, L.A.B.
AU  - Heinhuis, B.
AU  - Popa, C.
PY  - 2017
UR  - https://hdl.handle.net/2066/169697
AB  - Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the pathogenesis of RA and might be linked to the development of atherosclerosis. However, the exact mechanism linking IL-32 to CVD still needs to be elucidated. The influence of a functional genetic variant of IL-32 on lipid profiles and CVD risk was therefore studied in whole blood from individuals from the NBS cohort and RA patients from 2 independent cohorts. Lipid profiles were matched to the specific IL-32 genotypes. Allelic distribution was similar in all three groups. Interestingly, significantly higher levels of high density lipoprotein cholesterol (HDLc) were observed in individuals from the NBS cohort and RA patients from the Nijmegen cohort homozygous for the C allele (p = 0.0141 and p = 0.0314 respectively). In contrast, the CC-genotype was associated with elevated low density lipoprotein cholesterol (LDLc) and total cholesterol (TC) in individuals at higher risk for CVD (plaque positive) (p = 0.0396; p = 0.0363 respectively). Our study shows a functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD.
TI  - IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis
SN  - 2045-2322
JF  - Scientific Reports
VL  - vol. 7
DO  - https://doi.org/10.1038/srep41629
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/169697/169697.pdf?sequence=1
ER  -