TY  - JOUR
AU  - Eissing, M.L.L.G.
AU  - Ripken, L.S.
AU  - Schreibelt, G.
AU  - Westdorp, H.
AU  - Ligtenberg, M.J.
AU  - Netea-Maier, R.T.
AU  - Netea, M.G.
AU  - Vries, I.J.M. de
AU  - Hoogerbrugge, N.
PY  - 2018
UR  - https://hdl.handle.net/2066/200303
AB  - Carriers of a pathogenic germline mutations in the PTEN gene, a well-known tumor suppressor gene, are at increased risk of multiple benign and malignant tumors, e.g. breast, thyroid, endometrial and colon cancer. This is called PTEN Hamartomous Tumor Syndrome (PHTS). PHTS patients may also have an increased risk of immunological dysregulation, such as autoimmunity and immune deficiencies. The effects of PTEN on the immune system have been studied in murine knockout models demonstrating that loss of PTEN function leads to dysregulation of the immune response. This results in susceptibility to autoimmunity, impaired B cell class switching with subsequent hypogammaglobulinemia. Additionally, a decreased ability of dendritic cells to prime CD8(+) T cells was observed, leading to impaired tumor eradication. Immune dysfunction in PHTS patients has not yet been extensively studied but might be a manageable contributing factor to the increased cancer risk in PHTS.
TI  - PTEN Hamartoma Tumor Syndrome and Immune Dysregulation
EP  - 367
SN  - 1936-5233
IS  - iss. 2
SP  - 361
JF  - Translational Oncology
VL  - vol. 12
DO  - https://doi.org/10.1016/j.tranon.2018.11.003
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/200303/200303.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Lachmandas, E.L.
AU  - Thiem, K.
AU  - Heuvel, C.N.A.M. van den
AU  - Hijmans, A.G.M.
AU  - Galan, B.E. de
AU  - Tack, C.J.
AU  - Netea, M.G.
AU  - Crevel, R. van
AU  - Diepen, J.A. van
PY  - 2018
UR  - https://hdl.handle.net/2066/183988
TI  - Patients with type 1 diabetes mellitus have impaired IL-1 beta production in response to Mycobacterium tuberculosis
EP  - 380
SN  - 0934-9723
IS  - iss. 2
SP  - 371
JF  - European Journal of Clinical Microbiology and Infectious Diseases
VL  - vol. 37
DO  - https://doi.org/10.1007/s10096-017-3145-y
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/183988/183988.pdf?sequence=1
ER  -