Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy

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Title:	Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy
Author(s):	Wimmers, F.; Aarntzen, E.H.J.G. ; Schreibelt, G. ; Jacobs, J.F.M. ; Punt, C.J.A. ; Figdor, C.G. ; Vries, I.J.M. de
Publication year:	2014
Source:	Oncoimmunology, vol. 3, iss. 1, (2014), pp. e27219
ISSN:	2162-4011
DOI:	https://doi.org/10.4161/onci.27219
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/137869
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Subject:	Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health Sciences Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Tumorimmunology Radiology & Nuclear Medicine Laboratory of Medical Immunology Laboratory Medicine Paediatrics Radboudumc Extern Medical Oncology
Journal title:	Oncoimmunology
Volume:	vol. 3
Issue:	iss. 1
Page start:	p. e27219
Abstract:	Bioassays that predict clinical outcome are essential to optimize cellular anticancer immunotherapy. We have recently developed a robust and simple skin test to evaluate the capacity of tumor-specific T cells to migrate, recognize their targets and exert effector functions. This bioassay detects T cells with an elevated antineoplastic potential and hence rapidly identifies patients responding to immunotherapy.