cCMP is a substrate for MRP5
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Publication year
2014Source
Naunyn-Schmiedeberg's Archives of Pharmacology, 387, 9, (2014), pp. 893-5ISSN
Publication type
Article / Letter to editor
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Organization
Pharmacology-Toxicology
Journal title
Naunyn-Schmiedeberg's Archives of Pharmacology
Volume
vol. 387
Issue
iss. 9
Page start
p. 893
Page end
p. 5
Subject
Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life SciencesAbstract
The cyclic pyrimidine nucleotide cCMP has been suggested to serve as second messenger. However, phosphodiesterases studied so far do not hydrolyze cCMP. Therefore, we searched for alternative cCMP inactivation mechanisms. cCMP is a substrate for multidrug resistance protein 5, indicating that export from the cytosol into the extracellular space is an important inactivation mechanism for cCMP.
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- Academic publications [242559]
- Electronic publications [129545]
- Faculty of Medical Sciences [92285]
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