Treatment options for hypertriglyceridemia: from risk reduction to pancreatitis
SourceBest Practice & Research Clinical Endocrinology & Metabolism, 28, 3, (2014), pp. 423-437
Article / Letter to editor
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Best Practice & Research Clinical Endocrinology & Metabolism
SubjectRadboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences
While there has been considerable focus on the role and treatment of LDL cholesterol levels, a definitive role of triglycerides in the management of cardiovascular disease has been uncertain. Notably, with increasing triglyceride levels, there is a parallel increase in cholesterol levels carried by triglyceride-rich lipoproteins, which has prompted interest in the use of non-HDL cholesterol levels as a tool guiding interventions. Recent studies have provided evidence for an independent role of triglyceride levels as a cardiovascular risk factor, and recently, an Endocrine Society guideline was published for treatment of hypertriglyceridemia. In contrast to the relative uncertainty regarding triglycerides and cardiovascular disease, a role of very high triglyceride levels as a risk factor for pancreatitis has been well known. The present paper summarizes the underlying evidence for a risk role for triglyceride levels in cardiovascular disease and pancreatitis, current treatment recommendations and areas of future research.
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