Differential effects of the ApoE4 genotype on brain structure and function

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Title:	Differential effects of the ApoE4 genotype on brain structure and function
Author(s):	Matura, S.; Prvulovic, D.; Jurcoane, A.; Hartmann, D.; Miller, J.; Scheibe, M.; O'Dwyer, L.G. ; Oertel-Knochel, V.; Knochel, C.; Reinke, B.; Karakaya, T.; Fusser, F.; Pantel, J.
Publication year:	2014
Source:	NeuroImage, vol. 89, (2014), pp. 81-91
ISSN:	1053-8119
DOI:	https://doi.org/10.1016/j.neuroimage.2013.11.042
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/136251
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Subject:	Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
Organization:	Cognitive Neuroscience
Journal title:	NeuroImage
Volume:	vol. 89
Page start:	p. 81
Page end:	p. 91
Abstract:	The apolipoprotein E epsilon4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain macro- and microstructure, cognitive functioning and brain activity in fifty healthy young subjects (25 ApoE epsilon4 (epsilon4+) carriers and 25 non-carriers (epsilon4-), mean age 26.4+/-4.6years). We used diffusion tensor imaging (DTI) and voxel based morphometry (VBM) to assess brain structure, an extensive neuropsychological battery to test cognitive functioning and event-related functional magnetic resonance imaging (fMRI) to capture brain activity during episodic memory encoding and retrieval. ApoE epsilon4 carriers differed from non-carriers in fMRI activations but not in cognitive performance nor in brain micro- and macrostructure. These results suggest functional alterations in the episodic memory network that are modulated by the epsilon4 allele and might precede clinical or structural neurodegeneration.