[Determination of blood levels for oral anticancer drugs]
SourceNederlands Tijdschrift voor Geneeskunde, 158, 0, (2014), pp. A7884
Article / Letter to editor
Display more detailsDisplay less details
Nederlands Tijdschrift voor Geneeskunde
SubjectRadboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Oral tyrosine kinase inhibitors and mammalian target of rapamycin (mTOR) inhibitors are indicated in several types of cancer. They are usually administered at a fixed dose. In recent years, observational studies have reported on the wide variability in exposure to these new drugs, and the relationship between clinical response (efficacy and toxicity) and target plasma concentrations. Additionally, we are gaining insight into different food and drug interactions with these new drugs. On the basis of current drug monitoring, advice can be given on individual dosing of pazopanib in metastatic renal cell cancer (mRCC), sunitinib in mRCC and gastrointestinal stromal tumor (GIST), and imatinib in GIST.
Upload full text