[Added value of clopidogrel in cardiology and neurology]
SourceNederlands Tijdschrift voor Geneeskunde, 158, 0, (2014), pp. A7609
Article / Letter to editor
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Nederlands Tijdschrift voor Geneeskunde
SubjectRadboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences
- Platelet aggregation inhibitors reduce the risk of complications during and after acute coronary syndromes and after a TIA or stroke.- Acetylsalicylic acid plays a major role in secondary prevention; the combination of acetylsalicylic acid and a platelet ADP receptor antagonist, such as clopidogrel, may have added value.- In percutaneous coronary intervention, dual platelet inhibition appears to be effective in the prevention of stent thrombosis.- Long-term (> 1 year) use of dual platelet inhibition has an unfavourable risk-benefit profile, partly due to an increase in the number of bleeding events, particularly in the stomach.- The use of the combination of acetylsalicylic acid and clopidogrel may be helpful after a TIA or minor stroke, but further research is needed to identify the group of patients for whom this combination would be applicable.- This article provides an overview of the modern cardiological and neurological indications for platelet inhibition as well as the risk factors for severe bleeding events when using dual antiplatelet therapy.
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