Visuospatial working memory in ADHD patients, unaffected siblings, and healthy controls

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Title:	Visuospatial working memory in ADHD patients, unaffected siblings, and healthy controls
Author(s):	Ewijk, H. van; Heslenfeld, D.J.; Luman, M.; Rommelse, N.N.J. ; Hartman, C.A.; Hoekstra, P.; Franke, B. ; Buitelaar, J.K. ; Oosterlaan, J.
Publication year:	2014
Source:	Journal of Attention Disorders, vol. 18, iss. 4, (2014), pp. 369-378
ISSN:	1087-0547
DOI:	https://doi.org/10.1177/1087054713482582
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/136155
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Subject:	Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
Organization:	Psychiatry Human Genetics Cognitive Neuroscience PI Group MR Techniques in Brain Function
Journal title:	Journal of Attention Disorders
Volume:	vol. 18
Issue:	iss. 4
Page start:	p. 369
Page end:	p. 378
Abstract:	OBJECTIVE: The aim of this study was to (a) test the usefulness of visuospatial working memory (VSWM) as an endophenotype for ADHD and (b) study the developmental trajectory of VSWM in ADHD. METHOD: A total of 110 ADHD patients, 60 unaffected siblings, and 109 controls, aged 8 to 29 years, were assessed on VSWM functioning. Multilevel analyses were carried out to account for the correlation between measurements within families. RESULTS: ADHD patients showed impaired VSWM performance compared with unaffected siblings and controls, with comparable performance between unaffected siblings and controls. Impaired VSWM in ADHD patients was not more pronounced on higher memory loads, signifying executive rather than storage deficits as an underlying mechanism. ADHD patients, unaffected siblings, and controls showed parallel developmental trajectories of VSWM. CONCLUSION: Current findings question the usefulness of VSWM as a neurocognitive endophenotype for ADHD and provide unique insights into the developmental trajectory of VSWM in ADHD.