Publication year
2014Source
Journal of Attention Disorders, 18, 4, (2014), pp. 369-378ISSN
Publication type
Article / Letter to editor

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Organization
Psychiatry
Human Genetics
Cognitive Neuroscience
PI Group Memory and Emotion
Journal title
Journal of Attention Disorders
Volume
vol. 18
Issue
iss. 4
Page start
p. 369
Page end
p. 378
Subject
Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical NeuroscienceAbstract
OBJECTIVE: The aim of this study was to (a) test the usefulness of visuospatial working memory (VSWM) as an endophenotype for ADHD and (b) study the developmental trajectory of VSWM in ADHD. METHOD: A total of 110 ADHD patients, 60 unaffected siblings, and 109 controls, aged 8 to 29 years, were assessed on VSWM functioning. Multilevel analyses were carried out to account for the correlation between measurements within families. RESULTS: ADHD patients showed impaired VSWM performance compared with unaffected siblings and controls, with comparable performance between unaffected siblings and controls. Impaired VSWM in ADHD patients was not more pronounced on higher memory loads, signifying executive rather than storage deficits as an underlying mechanism. ADHD patients, unaffected siblings, and controls showed parallel developmental trajectories of VSWM. CONCLUSION: Current findings question the usefulness of VSWM as a neurocognitive endophenotype for ADHD and provide unique insights into the developmental trajectory of VSWM in ADHD.
This item appears in the following Collection(s)
- Academic publications [202801]
- Donders Centre for Cognitive Neuroimaging [3354]
- Faculty of Medical Sciences [80020]
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