The usefulness of systematic reviews of animal experiments for the design of preclinical and clinical studies
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Publication year
2014Source
Ilar Journal, 55, 3, (2014), pp. 427-37ISSN
Publication type
Article / Letter to editor
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Organization
Central Animal Laboratory
Surgery
Journal title
Ilar Journal
Volume
vol. 55
Issue
iss. 3
Page start
p. 427
Page end
p. 37
Subject
Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences; Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health SciencesAbstract
The question of how animal studies should be designed, conducted, and analyzed remains underexposed in societal debates on animal experimentation. This is not only a scientific but also a moral question. After all, if animal experiments are not appropriately designed, conducted, and analyzed, the results produced are unlikely to be reliable and the animals have in effect been wasted. In this article, we focus on one particular method to address this moral question, namely systematic reviews of previously performed animal experiments. We discuss how the design, conduct, and analysis of future (animal and human) experiments may be optimized through such systematic reviews. In particular, we illustrate how these reviews can help improve the methodological quality of animal experiments, make the choice of an animal model and the translation of animal data to the clinic more evidence-based, and implement the 3Rs. Moreover, we discuss which measures are being taken and which need to be taken in the future to ensure that systematic reviews will actually contribute to optimizing experimental design and thereby to meeting a necessary condition for making the use of animals in these experiments justified.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122517]
- Faculty of Medical Sciences [90373]
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