Publication year
2014Source
Neuron, 81, 3, (2014), pp. 653-63ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Cognitive Neuroscience
Journal title
Neuron
Volume
vol. 81
Issue
iss. 3
Page start
p. 653
Page end
p. 63
Subject
Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical NeuroscienceAbstract
The action potential activity of single cortical neurons can evoke measurable sensory effects, but it is not known how spiking parameters and neuronal subtypes affect the evoked sensations. Here, we examined the effects of spike train irregularity, spike frequency, and spike number on the detectability of single-neuron stimulation in rat somatosensory cortex. For regular-spiking, putative excitatory neurons, detectability increased with spike train irregularity and decreasing spike frequencies but was not affected by spike number. Stimulation of single, fast-spiking, putative inhibitory neurons led to a larger sensory effect compared to regular-spiking neurons, and the effect size depended only on spike irregularity. An ideal-observer analysis suggests that, under our experimental conditions, rats were using integration windows of a few hundred milliseconds or more. Our data imply that the behaving animal is sensitive to single neurons' spikes and even to their temporal patterning.
This item appears in the following Collection(s)
- Academic publications [245263]
- Faculty of Medical Sciences [93208]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.