Serum AMH levels in women with a history of preeclampsia suggest a role for vascular factors in ovarian aging
Publication year
2014Source
Journal of Clinical Endocrinology and Metabolism, 99, 2, (2014), pp. 579-86ISSN
Publication type
Article / Letter to editor
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Organization
Cardiology
Gynaecology
Journal title
Journal of Clinical Endocrinology and Metabolism
Volume
vol. 99
Issue
iss. 2
Page start
p. 579
Page end
p. 86
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health SciencesAbstract
Context: The association between early menopause and vascular disease as a possible causative factor has recently received attention. Preeclampsia (PE) is associated with future cardiovascular risk factors, and this premature vascular aging potentially modifies the ovarian aging process. OBJECTIVE: The purpose of this study was to assess whether women with a history of PE have lower anti-Mullerian hormone (AMH) levels than women with normotensive pregnancies. DESIGN: This was a retrospective cohort study. SETTING: The study was conducted in a tertiary referral center. PATIENTS: Clinical data and blood samples of participants in the Preeclampsia Risk EValuation in FEMales study were used (336 women with a history of PE and 329 women after a normotensive pregnancy). Interventions: There were no interventions. MAIN OUTCOME MEASURES: The relative decrease in AMH levels was assessed after a median follow-up of 10.5 years. RESULTS: The mean AMH level was 2.00 +/- 1.87 mug/L in the PE group compared with 2.26 +/- 2.56 mug/L in the reference group. Linear regression analysis with censoring for undetectable AMH levels, adjusted for age, smoking, and hormonal contraceptive use, showed a relative reduction in AMH levels of 20.9% at any age (fold change 0.79, 95% confidence interval, 0.67-0.94). CONCLUSIONS: We demonstrate that women with a history of PE have significantly lower AMH levels than women with normotensive pregnancies. Calculations based on a reference population indicate advancement of reproductive age of approximately 1.5 years. Because PE is considered a manifestation of impaired vascular health, these results support the hypothesis that compromised vascular health could act as a causative mechanism in early ovarian aging.
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- Academic publications [245011]
- Faculty of Medical Sciences [93198]
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