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Title: Serotonin 1A receptors and sexual behavior in male rats: a review.
Author(s): Snoeren, E.M.; Veening, J.G. ; Olivier, B.; Oosting, R.S.
Publication year: 2014
Source: Pharmacology, Biochemistry and Behavior, vol. 121, (2014), pp. 102-114
ISSN: 0091-3057
DOI: https://doi.org/10.1016/j.pbb.2013.11.007
Annotation: 1 juni 2014
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/133885   https://hdl.handle.net/2066/133885

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Subject: Radboudumc 0: Other Research DCMN: Donders Center for Medical Neuroscience
Organization: Anatomy
Psychoneuropharmacology
Journal title:
Pharmacology, Biochemistry and Behavior
Volume: vol. 121
Page start: p. 102
Page end: p. 114
Abstract:
Serotonin plays an important role in male sexual behavior. Many studies have been performed on the pivotal role of 5-HT(1)A receptors in sexual behavior. Overall, 5-HT(1)A receptors do not appear to be involved under normal circumstances, but become very important under conditions of elevated serotonin levels in sexual behavior. 5-HT(1)A receptor agonists facilitate ejaculatory behavior in male rats, while inhibiting copulatory behavior. Three different phases can be distinguished in rats' sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. Different mechanisms and brain regions are involved in these phases. The mechanisms, brain regions and the possible involvement of 5-HT and 5-HT(1)A receptors in the appropriate phases in male rat sexual behavior will be discussed in the current review.

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