3D in vitro cell culture models of tube formation

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Title:	3D in vitro cell culture models of tube formation
Author(s):	Zegers, M.M.P.
Publication year:	2014
Source:	Seminars in Cell & Developmental Biology, vol. 31C, (2014), pp. 132-140
ISSN:	1084-9521
DOI:	https://doi.org/10.1016/j.semcdb.2014.02.016
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/133815
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Subject:	Radboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Cell Biology (UMC)
Journal title:	Seminars in Cell & Developmental Biology
Volume:	vol. 31C
Page start:	p. 132
Page end:	p. 140
Abstract:	Building the complex architecture of tubular organs is a highly dynamic process that involves cell migration, polarization, shape changes, adhesion to neighboring cells and the extracellular matrix, physicochemical characteristics of the extracellular matrix and reciprocal signaling with the mesenchyme. Understanding these processes in vivo has been challenging as they take place over extended time periods deep within the developing organism. Here, I will discuss 3D in vitro models that have been crucial to understand many of the molecular and cellular mechanisms and key concepts underlying branching morphogenesis in vivo.