Specificity of performance monitoring changes in obsessive-compulsive disorder

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Title:	Specificity of performance monitoring changes in obsessive-compulsive disorder
Author(s):	Endrass, T.; Ullsperger, M.
Publication year:	2014
Source:	Neuroscience and Biobehavioral Reviews, vol. 46, iss. Part 1, (2014), pp. 124-138
Number of Pages:	15 p.
ISSN:	0149-7634
DOI:	https://doi.org/10.1016/j.neubiorev.2014.03.024
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/133436
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Subject:	Biological psychology DI-BCB_DCC_Theme 2: Perception, Action and Control Biologische psychologie
Organization:	SW OZ DCC SMN
Journal title:	Neuroscience and Biobehavioral Reviews
Volume:	vol. 46
Issue:	iss. Part 1
Page start:	p. 124
Page end:	p. 138
Abstract:	Obsessive-compulsive disorder (OCD) is characterized by overactivity in frontal and striatal brain regions, and event-related potential studies have shown increased brain activity during performance monitoring. The error-related negativity (ERN) is a component of the event-related potential that is observed following incorrect responses, and signals the need for behavioral adjustments. ERN enhancements have even been considered as a biomarker or endophenotype of OCD. However over the past years, enhanced ERN amplitudes, although less reliably, were also found in anxiety and affective disorders. These results question the specificity of ERN alterations to OCD. The present review summarizes current findings on performance monitoring and feedback processing in OCD and their relation to behavioral measures. Further, it discusses possible differential mechanisms contributing to amplitude variations in different clinical conditions.
Languages used:	English (eng)