Proactive control of sequential saccades in the human supplementary eye field
Publication year
2013Source
Proceedings of the National Academy of Sciences USA, 110, 14, (2013), pp. E1311-E1320ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ DCC CO
Journal title
Proceedings of the National Academy of Sciences USA
Volume
vol. 110
Issue
iss. 14
Page start
p. E1311
Page end
p. E1320
Subject
Action, intention, and motor control; DI-BCB_DCC_Theme 2: Perception, Action and ControlAbstract
Our ability to regulate behavior based on past experience has thus far been examined using single movements. However, natural behavior typically involves a sequence of movements. Here, we examined the effect of previous trial type on the concurrent planning of sequential saccades using a unique paradigm. The task consisted of two trial types: no-shift trials, which implicitly encouraged the concurrent preparation of the second saccade in a subsequent trial; and target-shift trials, which implicitly discouraged the same in the next trial. Using the intersaccadic interval as an index of concurrent planning, we found evidence for context-based preparation of sequential saccades. We also used functional MRI-guided, single-pulse, transcranial magnetic stimulation on human subjects to test the role of the supplementary eye field (SEF) in the proactive control of sequential eye movements. Results showed that (i) stimulating the SEF in the previous trial disrupted the previous trial type-based preparation of the second saccade in the nonstimulated current trial, (ii) stimulating the SEF in the current trial rectified the disruptive effect caused by stimulation in the previous trial, and (iii) stimulating the SEF facilitated the preparation of second saccades based on previous trial type even when the previous trial was not stimulated. Taken together, we show how the human SEF is causally involved in proactive preparation of sequential saccades.
This item appears in the following Collection(s)
- Academic publications [202923]
- Electronic publications [101091]
- Faculty of Social Sciences [27123]
- Open Access publications [69755]
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