Physical activity is related to the structural integrity of cerebral white matter

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Title:	Physical activity is related to the structural integrity of cerebral white matter
Author(s):	Gons, R.A.R. ; Tuladhar, A.M. ; Laat, K.F. de ; Norden, A.G.W. van ; Dijk, E.J. van ; Norris, D.G. ; Zwiers, M.P. ; Leeuw, F.E. de
Publication year:	2013
Source:	Neurology, vol. 81, iss. 11, (2013), pp. 971-976
ISSN:	0028-3878
DOI:	https://doi.org/10.1212/WNL.0b013e3182a43e33
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/128550
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Subject:	150 000 MR Techniques in Brain Function Biophysics DCN MP - Plasticity and memory DCN MP - Plasticity and memory NCEBP 14: Cardiovascular diseases DCN NN - Brain networks and neuronal communication DCN NN - Brain networks and neuronal communication NCEBP 9 - Mental health DCN PAC - Perception action and control
Organization:	Neurology Donders Centre for Cognitive Neuroimaging PI Group MR Techniques in Brain Function Cognitive Neuroscience
Journal title:	Neurology
Volume:	vol. 81
Issue:	iss. 11
Page start:	p. 971
Page end:	p. 976
Abstract:	OBJECTIVE: To investigate the relation between physical exercise and the microstructural integrity of cerebral white matter. METHODS: Four hundred forty individuals with cerebral small-vessel disease, aged between 50 and 85 years, without dementia, were included and underwent MRI scanning. Physical exercise was assessed with a structured questionnaire. The cross-sectional relation between physical exercise and the microstructural integrity of the white matter was assessed by applying Tract-Based Spatial Statistics to diffusion tensor imaging parameters. RESULTS: Being more physically active was negatively related to the mean, axial, and radial diffusivity in numerous regions of the white matter, indicative of higher white matter integrity. CONCLUSIONS: These data indicate an association between physical activity and the integrity of the cerebral white matter's microstructure. Prospective studies are required to investigate a possible causal association between physical activity and cognitive decline.