Publication year
2014Source
Advances in Chronic Kidney Disease, 21, 2, (2014), pp. 166-181ISSN
Publication type
Article / Letter to editor

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Organization
Nephrology
Journal title
Advances in Chronic Kidney Disease
Volume
vol. 21
Issue
iss. 2
Page start
p. 166
Page end
p. 181
Subject
Radboudumc 11: Renal disorders RIHS: Radboud Institute for Health SciencesAbstract
Membranous nephropathy, focal segmental glomerulosclerosis (FSGS), and minimal change disease (MCD) are the most common causes of idiopathic nephrotic syndrome. For many years prednisone, alkylating agents, and calcineurin inhibitors have been the standard of therapy for these patients. More effective or better tolerated treatment modalities are needed. B cell targeted therapy was recently introduced in clinical practice. In this review, we briefly summarize the current standard therapy and discuss the efficacy of B cell targeted therapy in primary glomerular diseases. Observational, short-term studies suggest that rituximab is effective and comparable to standard therapy in maintaining remissions in patients with frequently relapsing or steroid-dependent MCD or FSGS. In contrast, response is limited in patients with steroid-resistant nephrotic syndrome. Rituximab also induces remissions in patients with membranous nephropathy. Controlled clinical trials on kidney endpoints are urgently needed to position B cell targeted therapy in clinical practice.
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- Academic publications [202828]
- Faculty of Medical Sciences [80037]
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