A RAG driver on the road to pediatric ALL

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Title:	A RAG driver on the road to pediatric ALL
Author(s):	Kuiper, R.P. ; Waanders, E.
Publication year:	2014
Source:	Nature Genetics, vol. 46, iss. 2, (2014), pp. 96-98
ISSN:	1061-4036
DOI:	http://dx.doi.org/10.1038/ng.2879
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/127650
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Subject:	Radboudumc 14: Tumours of the digestive tract RIMLS: Radboud Institute for Molecular Life Sciences Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Human Genetics
Journal title:	Nature Genetics
Volume:	vol. 46
Issue:	iss. 2
Page start:	p. 96
Page end:	p. 98
Abstract:	Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.