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Publication year
2014Source
Neuropsychologia, 53, (2014), pp. 171-177ISSN
Publication type
Article / Letter to editor

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Organization
PI Group Motivational & Cognitive Control
Human Genetics
Psychiatry
PI Group MR Techniques in Brain Function
Cognitive Neuroscience
PI Group Memory and Emotion
Journal title
Neuropsychologia
Volume
vol. 53
Page start
p. 171
Page end
p. 177
Subject
150 000 MR Techniques in Brain Function; 170 000 Motivational & Cognitive Control; Radboudumc 0: Other Research DCMN: Donders Center for Medical Neuroscience; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical NeuroscienceAbstract
Ample evidence shows that the basal ganglia play an important role in cognitive flexibility. However, traditionally, cognitive processes have most commonly been associated with the prefrontal cortex. Indeed, current theoretical models of basal ganglia function suggest the basal ganglia interact with the prefrontal cortex and thalamus, via anatomical fronto-striato-thalamic circuits, to implement cognitive flexibility. Here we aimed to assess this hypothesis in humans by associating individual differences in cognitive flexibility with white matter microstructure of the basal ganglia. To this end we employed an attention switching paradigm in adults with ADHD and controls, leading to a broad range in task performance. Attention switching performance could be predicted based on individual differences in white matter microstructure in/around the basal ganglia. Crucially, local white matter showing this association projected to regions in the prefrontal cortex and thalamus. Our findings highlight the crucial role of the basal ganglia and the fronto-striato-thalamic circuit for cognitive flexibility.
This item appears in the following Collection(s)
- Academic publications [203856]
- Donders Centre for Cognitive Neuroimaging [3391]
- Electronic publications [102283]
- Faculty of Medical Sciences [80326]
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