The influence of diazepam on the electroencephalogram-evoked potential interrelation in rats
SourceNeuroscience Letters, 293, 2, (2000), pp. 83-86
Article / Letter to editor
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SW OZ DCC SMN
Though being a sedative increases b-activity in the electroencephalogram (EEG). Diazepam also affects auditory evoked potentials (AEPs). We investigated if the effect of diazepam on AEPs could be ascribed to its b-increasing effect. Eight rats received vehicle and diazepam counterbalanced. AEPs were ranked in ten categories according to the percentages of b-activity in the pre-stimulus electroencephalogram (EEG). With vehicle, the P29, N51 and P67 AEP components increased and cross-coorelation coefficients (CCCs) declined with increasing b-activity. With diazepam AEP components and CCCs remained unchanged. AllAEPs with diazepam closely resembled the AEP of the lowest b-category obtained with vehicle. We conclude that the effect of diazepam on AEPs can not be ascribed to its b-enhancing effect. Diazepam disrupts the normal AEP-EEG relation such that diazepam-effects in AEPs seem to reflect sedative effects of diazepam and not its b-increasing effects.
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