TY  - JOUR
AU  - Gaalen, J. van
AU  - Swart, B.J. de
AU  - Oostveen, J.M.
AU  - Knuijt, S.
AU  - Warrenburg, B.P.C. van de
AU  - Kremer, H.P.H.
PY  - 2014
UR  - http://hdl.handle.net/2066/138525
AB  - BACKGROUND: Several studies have suggested that language impairment can be observed in patients with cerebellar pathology. The aim of this study was to investigate language performance in patients with spinocerebellar ataxia type 6 (SCA6). METHODS: We assessed speech and language in 29 SCA6 patients with standardized linquistic tests and correlated this with the severity of ataxia, as quantified by the Scale of Assessment and Rating of Ataxia. RESULTS: Individual patients show mild-to-moderate linguistic impairment. Linguistic abnormalities were most distinct on the writing and comprehension subtests. A strong correlation between severity of ataxia and linguistic performance was consistently found. CONCLUSIONS: This study confirms the occurrence of linguistic impairments in patients with cerebellar degenerative diseases, such as SCA6. The relation between linguistic abnormalities and severity of ataxia provides further evidence for a role of the cerebellum in linguistic processing. (c) 2014 International Parkinson and Movement Disorder Society.
TI  - Language impairment in cerebellar ataxia
EP  - 1312
SN  - 0885-3185
IS  - iss. 10
SP  - 1307
JF  - Movement Disorders
VL  - vol. 29
DO  - https://doi.org/10.1002/mds.25854
ER  - 
TY  - JOUR
AU  - Kalf, J.G.
AU  - Swart, B.J.M. de
AU  - Borm, G.F.
AU  - Bloem, B.R.
AU  - Munneke, M.
PY  - 2009
UR  - http://hdl.handle.net/2066/81872
AB  - Drooling (saliva loss) is a frequently reported symptom in patients with Parkinson's disease (PD), but an accurate estimate of the prevalence of drooling is lacking. The aim of this study was to systematically review the prevalence of drooling in published research papers. A systematic PubMed and CINAHL search was done, including studies published until January 2009. Eight studies were found, presenting prevalence rates of drooling based on responses of PD patients to questionnaires. The statistical heterogeneity was highly significant (P < 0.0001), with prevalence rates ranging from 32 to 74%. The pooled prevalence estimate with random effect analysis was of 56% (95% CI 44-67) for PD patients and 14% (95% CI 3-25) for healthy controls; the pooled relative risk (RR) with random effect analysis was 5.5 (95% CI 2.1-14.4). All studies reported data of community dwelling idiopathic PD patients, with a mean age around 65 years and mild PD in 50-60% of the cases. Heterogeneity was mainly caused by differences in definition or frequency of drooling. The highest prevalence rates included nocturnal drooling where others noted only diurnal drooling. Analysis of the data of two studies showed that drooling is reported frequently by 22-26% of the patients. Prevalence rates were lower in milder PD patients. The summarized findings demonstrate that drooling can be present in half of all PD patients. In about a quarter of PD patients, drooling appears to be a frequently occurring problem. We recommend to report drooling in future studies with more detailed consideration of severity, frequency and nocturnal versus diurnal complaints.
TI  - Prevalence and definition of drooling in Parkinson's disease: a systematic review.
EP  - 1396
SN  - 0340-5354
IS  - iss. 9
SP  - 1391
JF  - Journal of Neurology
VL  - vol. 256
DO  - http://dx.doi.org/10.1007/s00415-009-5098-2
ER  - 
TY  - JOUR
AU  - Kalf, J.G.
AU  - Swart, B.J.M. de
AU  - Bloem, B.R.
AU  - Munneke, M.
PY  - 2009
UR  - http://hdl.handle.net/2066/81876
TI  - Prevalence of drooling in Parkinson's disease: a matter of definition
EP  - S529
SN  - 0885-3185
IS  - iss. 1
SP  - S529
JF  - Movement Disorders
VL  - vol. 24
ER  - 
TY  - JOUR
AU  - Kalf, J.G.
AU  - Engel-Hoek, L. van den
AU  - Bloem, B.R.
AU  - Munneke, M.A.M.
AU  - Swart, B.J.M. de
AU  - Zwarts, M.J.
PY  - 2009
UR  - http://hdl.handle.net/2066/80914
TI  - Drooling in Parkinson's disease is a motor disorder
EP  - S529
SN  - 0885-3185
IS  - iss. 1
SP  - S529
JF  - Movement Disorders
VL  - vol. 24
ER  - 
TY  - JOUR
AU  - Kalf, J.G.
AU  - Swart, B.J.M. de
AU  - Bloem, B.R.
PY  - 2008
UR  - http://hdl.handle.net/2066/71119
TI  - Richtlijn Logopedie bij de ziekte van Parkinson.
EP  - 363
SN  - 1571-5930
IS  - iss. 8
SP  - 358
JF  - Tijdschrift voor Neurologie & Neurochirurgie
VL  - vol. 109
ER  - 
TY  - JOUR
AU  - Kalf, J.G.
AU  - Swart, B.J.M. de
AU  - Bloem, B.R.
AU  - Munneke, M.
PY  - 2008
UR  - http://hdl.handle.net/2066/69480
TI  - Logopedie bij de ziekte van Parkinson; introductie en samenvatting van de NVLF-richtlijn.
EP  - 280
SN  - 0166-252X
IS  - iss. 10
SP  - 269
JF  - Logopaedie en Phoniatrie
VL  - vol. 81
ER  -