TY - JOUR AU - Drijvers, L. AU - Plas, M. van der AU - Özyürek, A. AU - Jensen, O. PY - 2019 UR - http://hdl.handle.net/2066/201952 AB - Listeners are often challenged by adverse listening conditions during language comprehension induced by external factors, such as noise, but also internal factors, such as being a non-native listener. Visible cues, such as semantic information conveyed by iconic gestures, can enhance language comprehension in such situations. Using magnetoencephalography (MEG) we investigated whether spatiotemporal oscillatory dynamics can predict a listener's benefit of iconic gestures during language comprehension in both internally (non-native versus native listeners) and externally (clear/degraded speech) induced adverse listening conditions. Proficient non-native speakers of Dutch were presented with videos in which an actress uttered a degraded or clear verb, accompanied by a gesture or not, and completed a cued-recall task after every video. The behavioral and oscillatory results obtained from non-native listeners were compared to an MEG study where we presented the same stimuli to native listeners (Drijvers et al., 2018a). Non-native listeners demonstrated a similar gestural enhancement effect as native listeners, but overall scored significantly slower on the cued-recall task. In both native and non-native listeners, an alpha/beta power suppression revealed engagement of the extended language network, motor and visual regions during gestural enhancement of degraded speech comprehension, suggesting similar core processes that support unification and lexical access processes. An individual's alpha/beta power modulation predicted the gestural benefit a listener experienced during degraded speech comprehension. Importantly, however, non-native listeners showed less engagement of the mouth area of the primary somatosensory cortex, left insula (beta), LIFG and ATL (alpha) than native listeners, which suggests that non-native listeners might be hindered in processing the degraded phonological cues and coupling them to the semantic information conveyed by the gesture. Native and non-native listeners thus demonstrated similar yet distinct spatiotemporal oscillatory dynamics when recruiting visual cues to disambiguate degraded speech. TI - Native and non-native listeners show similar yet distinct oscillatory dynamics when using gestures to access speech in noise EP - 67 SN - 1053-8119 SP - 55 JF - NeuroImage VL - vol. 194 PS - 13 p. DO - https://doi.org/10.1016/j.neuroimage.2019.03.032 ER - TY - JOUR AU - Popov, T. AU - Jensen, O. AU - Schoffelen, J.M. PY - 2018 UR - http://hdl.handle.net/2066/191686 AB - Oscillatory activity in the alpha and gamma bands is considered key in shaping functional brain architecture. Power increases in the high-frequency gamma band are typically reported in parallel to decreases in the low-frequency alpha band. However, their functional significance and in particular their interactions are not well understood. The present study shows that, in the context of an N-back working memory task, alpha power decreases in the dorsal visual stream are related to gamma power increases in early visual areas. Granger causality analysis revealed directed interregional interactions from dorsal to ventral stream areas, in accordance with task demands. Present results reveal a robust, behaviorally relevant, and architectonically decisive power-to-power relationship between alpha and gamma activity. This relationship suggests that anatomically distant power fluctuations in oscillatory activity can link cerebral network dynamics on trial-by-trial basis during cognitive operations such as working memory. TI - Dorsal and ventral cortices are coupled by cross-frequency interactions during working memory EP - 286 SN - 1053-8119 SP - 277 JF - NeuroImage VL - vol. 178 DO - https://doi.org/10.1016/j.neuroimage.2018.05.054 ER - TY - JOUR AU - Marshall, T.R. AU - Esterer, S. AU - Herring, J.D. AU - Bergmann, T.O. AU - Jensen, O. PY - 2016 UR - http://hdl.handle.net/2066/163326 TI - On the relationship between cortical excitability and visual oscillatory responses - A concurrent tDCS-MEG study EP - 49 SN - 1053-8119 SP - 41 JF - NeuroImage VL - vol. 140 DO - https://doi.org/10.1016/j.neuroimage.2015.09.069 ER - TY - JOUR AU - Nieuwenhuijzen, M.E. van de AU - Axmacher, N. AU - Fell, J. AU - Oehrn, C.R. AU - Jensen, O. AU - Gerven, M.A.J. van PY - 2016 UR - http://hdl.handle.net/2066/158227 AB - Natural stimuli consist of multiple properties. However, not all of these properties are equally relevant in a given situation. In this study, we applied multivariate classification algorithms to intracranial electroencephalography data of human epilepsy patients performing an auditory Stroop task. This allowed us to identify neuronal representations of task-relevant and irrelevant pitch and semantic information of spoken words in a subset of patients. When properties were relevant, representations could be detected after about 350 ms after stimulus onset. When irrelevant, the association with gamma power differed for these properties. Patients with more reliable representations of irrelevant pitch showed increased gamma band activity (35-64 Hz), suggesting that attentional resources allow an increase in gamma power in some but not all patients. This effect was not observed for irrelevant semantics, possibly because the more automatic processing of this property allowed for less variation in free resources. Processing of different properties of the same stimulus seems therefore to be dependent on the characteristics of the property. TI - Decoding of task-relevant and task-irrelevant intracranial EEG representations EP - 139 SN - 1053-8119 SP - 132 JF - NeuroImage VL - vol. 137 PS - 8 p. DO - http://dx.doi.org/10.1016/j.neuroimage.2016.05.008 ER - TY - JOUR AU - Jiang, H. AU - Bahramisharif, A. AU - Gerven, M.A.J. van AU - Jensen, O. PY - 2015 UR - http://hdl.handle.net/2066/143490 AB - It is well established that neuronal oscillations at different frequencies interact with each other in terms of cross-frequency coupling (CFC). In particular, the phase of slower oscillations modulates the power of faster oscillations. This is referred to as phase-amplitude coupling (PAC). Examples are alpha phase to gamma power coupling as observed in humans and theta phase to gamma power coupling as observed in the rat hippocampus. We here ask if the interaction between alpha and gamma oscillations is in the direction of the phase of slower oscillations driving the power of faster oscillations or conversely from the power of faster oscillations driving the phase of slower oscillations. To answer this question, we introduce a new measure to estimate the cross-frequency directionality (CFD). This measure is based on the phase-slope index (PSI) between the phase of slower oscillations and the power envelope of faster oscillations. Further, we propose a randomization framework for statistically evaluating the coupling measures when controlling for multiple comparisons over the investigated frequency ranges. The method was firstly validated on simulated data and next applied to resting state electrocorticography (ECoG) data. These results demonstrate that the method works reliably. In particular, we found that the power envelope of gamma oscillations drives the phase of slower oscillations in the alpha band. This surprising finding is not easily reconcilable with theories suggesting that feedback controlled alpha oscillations modulate feedforward processing reflected in the gamma band. TI - Measuring directionality between neuronal oscillations of different frequencies EP - 367 SN - 1053-8119 SP - 359 JF - NeuroImage VL - vol. 118 PS - 9 p. DO - https://doi.org/10.1016/j.neuroimage.2015.05.044 ER - TY - JOUR AU - Okazaki, Y.O. AU - Horschig, J.M. AU - Luther, L.M. AU - Oostenveld, R. AU - Murakami, I. AU - Jensen, O. PY - 2015 UR - http://hdl.handle.net/2066/150742 AB - It has been demonstrated that alpha activity is lateralized when attention is directed to the left or right visual hemifield. We investigated whether real-time neurofeedback training of the alpha lateralization enhances participants' ability to modulate posterior alpha lateralization and causes subsequent short-term changes in visual detection performance. The experiment consisted of three phases: (i) pre-training assessment, (ii) neurofeedback phase and (iii) post-training assessment. In the pre- and post-training phases we measured the threshold to covertly detect a cued faint Gabor stimulus presented in the left or right hemifield. During magnetoencephalography (MEG) neurofeedback, two face stimuli superimposed with noise were presented bilaterally. Participants were cued to attend to one of the hemifields. The transparency of the superimposed noise and thus the visibility of the stimuli were varied according to the momentary degree of hemispheric alpha lateralization. In a double-blind procedure half of the participants were provided with sham feedback. We found that hemispheric alpha lateralization increased with the neurofeedback training; this was mainly driven by an ipsilateral alpha increase. Surprisingly, comparing pre- to post-training, detection performance decreased for a Gabor stimulus presented in the hemifield that was un-attended during neurofeedback. This effect was not observed in the sham group. Thus, neurofeedback training alters alpha lateralization, which in turn decreases performances in the untrained hemifield. Our findings suggest that alpha oscillations play a causal role for the allocation of attention. Furthermore, our neurofeedback protocol serves to reduce the detection of unattended visual information and could therefore be of potential use for training to reduce distractibility in attention deficit patients, but also highlights that neurofeedback paradigms can have negative impact on behavioral performance and should be applied with caution. (C) 2014 Elsevier Inc. All rights reserved. TI - Real-time MEG neurofeedback training of posterior alpha activity modulates subsequent visual detection performance EP - 332 SN - 1053-8119 SP - 323 JF - NeuroImage VL - vol. 107 PS - 10 p. DO - https://doi.org/10.1016/j.neuroimage.2014.12.014 ER - TY - JOUR AU - Vollebregt, M.A. AU - Zumer, J. AU - Huurne, N.P. ter AU - Castricum, J. AU - Buitelaar, J.K. AU - Jensen, O. AU - Zumer, J.M. PY - 2015 UR - http://hdl.handle.net/2066/149200 AB - The evidence for a functionally inhibitory role of alpha oscillations is growing stronger, mostly derived from studies in healthy adults investigating spatial attention. It remains unexplored if the modulation of alpha band oscillations plays a similar functional role in typically developing children. The aim of this study was to characterize alpha modulations in children in relation to attentional performance. To this end, the posterior alpha activity (8-12Hz) in children between 7 and 10years old was measured using EEG while they performed a visuospatial covert attention task. We found that the alpha activity decreased in the hemisphere contralateral to the attended hemifield, whereas it relatively increased in the other hemisphere. In addition, we found that the degree of lateralized alpha modulation predicted performance on the attention task by negatively predicting the response time on invalid trials. Of note, children who were behaviorally less influenced by spatial cueing also were children with a clear lateralized alpha modulation pattern, with a significantly stronger alpha lateralization in the left hemisphere than children who were influenced more by spatial cueing. In addition, a bias to the right visual field such as that commonly observed in children, was significantly smaller or absent in the children influenced least by spatial cueing. Among all children, the magnitude of this visual field bias was positively related to the ability to modulate alpha activity. In conclusion, we have shown that the pattern of alpha oscillations modulated by attention is already present in 7-10year old typically developing children. Although a similar pattern is observed in adults, the consequences for behavior are different. The fact that alpha modulation is already present at this age opens up the possibility of using hemispheric alpha lateralization as a tool to study the physiological basis of attention deficits in clinical disorders such as ADHD. TI - Lateralized modulation of posterior alpha oscillations in children EP - 252 SN - 1053-8119 SP - 245 JF - NeuroImage VL - vol. 123 PS - 8 p. DO - https://doi.org/10.1016/j.neuroimage.2015.06.054 ER - TY - JOUR AU - Whitmarsh, S. AU - Barendregt, H. AU - Schoffelen, J.M. AU - Jensen, O. PY - 2014 UR - http://hdl.handle.net/2066/126139 TI - Metacognitive awareness of covert somatosensory attention corresponds to contralateral alpha power EP - 809 SN - 1053-8119 SP - 803 JF - NeuroImage VL - vol. 85, Part 2 DO - https://doi.org/10.1016/j.neuroimage.2013.07.031 ER - TY - JOUR AU - Mazaheri, A. AU - Schouwenburg, M.R. van AU - Dimitrijevic, A. AU - Denys, D. AU - Cools, R. AU - Jensen, O. PY - 2014 UR - http://hdl.handle.net/2066/136684 AB - There have been a number of studies suggesting that oscillatory alpha activity (~10 Hz) plays a pivotal role in attention by gating information flow to relevant sensory regions. The vast majority of these studies have looked at shifts of attention in the spatial domain and only in a single modality (often visual or sensorimotor). In the current magnetoencephalography (MEG) study, we investigated the role of alpha activity in the suppression of a distracting modality stream. We used a cross-modal attention task where visual cues indicated whether participants had to judge a visual orientation or discriminate the auditory pitch of an upcoming target. The visual and auditory targets were presented either simultaneously or alone, allowing us to behaviorally gauge the "cost" of having a distractor present in each modality. We found that the preparation for visual discrimination (relative to pitch discrimination) resulted in a decrease of alpha power (9-11 Hz) in the early visual cortex, with a concomitant increase in alpha/beta power (14-16 Hz) in the supramarginal gyrus, a region suggested to play a vital role in short-term storage of pitch information (Gaab et al., 2003). On a trial-by-trial basis, alpha power over the visual areas was significantly correlated with increased visual discrimination times, whereas alpha power over the precuneus and right superior temporal gyrus was correlated with increased auditory discrimination times. However, these correlations were only significant when the targets were paired with distractors. Our work adds to increasing evidence that the top-down (i.e. attentional) modulation of alpha activity is a mechanism by which stimulus processing can be gated within the cortex. Here, we find that this phenomenon is not restricted to the domain of spatial attention and can be generalized to other sensory modalities than vision. TI - Region-specific modulations in oscillatory alpha activity serve to facilitate processing in the visual and auditory modalities EP - 362 SN - 1053-8119 SP - 356 JF - NeuroImage VL - vol. 87 PS - 7 p. DO - https://doi.org/10.1016/j.neuroimage.2013.10.052 ER - TY - JOUR AU - Horschig, J.M. AU - Jensen, O. AU - Schouwenburg, M.R. van AU - Cools, R. AU - Bonnefond, M. PY - 2014 UR - http://hdl.handle.net/2066/137463 AB - Recent findings suggest that oscillatory alpha activity (7-13Hz) is associated with functional inhibition of sensory regions by filtering incoming information. Accordingly the alpha power in visual regions varies in anticipation of upcoming, predictable stimuli which has consequences for visual processing and subsequent behavior. In covert spatial attention studies it has been demonstrated that performance correlates with the adaptation of alpha power in response to explicit spatial cueing. However it remains unknown whether such an adaptation also occurs in response to implicit statistical properties of a task. In a covert attention switching paradigm, we here show evidence that individuals differ on how they adapt to implicit statistical properties of the task. Subjects whose behavioral performance reflects the implicit change in switch trial likelihood show strong adjustment of anticipatory alpha power lateralization. Most importantly, the stronger the behavioral adjustment to the switch trial likelihood was, the stronger the adjustment of anticipatory posterior alpha lateralization. We conclude that anticipatory spatial attention is reflected in the distribution of posterior alpha band power which is predictive of individual detection performance in response to the implicit statistical properties of the task. TI - Alpha activity reflects individual abilities to adapt to the environment EP - 243 SN - 1053-8119 SP - 235 JF - NeuroImage VL - vol. 89 PS - 9 p. DO - https://doi.org/10.1016/j.neuroimage.2013.12.018 ER - TY - JOUR AU - Horschig, J.M. AU - Jensen, O. AU - Schouwenburg, M.R. van AU - Cools, R. AU - Bonnefond, M. PY - 2014 UR - http://hdl.handle.net/2066/158230 TI - Alpha activity reflects individual abilities to adapt to the environment EP - 243 SN - 1053-8119 SP - 235 JF - NeuroImage VL - vol. 89 PS - 9 p. DO - https://doi.org/10.1016/j.neuroimage.2013.12.018 ER - TY - JOUR AU - Nieuwenhuijzen, M.E. van de AU - Backus, A.R. AU - Bahramisharif, A. AU - Döller, C.F.A. AU - Jensen, O. AU - Gerven, M.A.J. van PY - 2013 UR - http://hdl.handle.net/2066/121165 AB - Visual processing is a complex task which is best investigated using sensitive multivariate analysis methods that can capture representation-specific brain activity over both time and space. In this study, we applied a multivariate decoding algorithm to MEG data of subjects engaged in passive viewing of images of faces, scenes, bodies and tools. We used reconstructed source-space time courses as input to the algorithm in order to localize brain regions involved in optimal image discrimination. Applying this method to the interval of 115 to 315 ms after stimulus onset, we show a focal localization of regression coefficients in the inferior occipital, middle occipital, and lingual gyrus that drive decoding of the different perceived image categories. Classifier accuracy was highest (over 90% correctly classified trials, compared to a chance level accuracy of 50%) when dissociating the perception of faces from perception of other object categories. Furthermore, we applied this method to each single time point to extract the temporal evolution of visual perception. This allowed for the detection of differences in visual category perception as early as 85 ms after stimulus onset. Furthermore, localizing the corresponding regression coefficients of each time point allowed us to capture the spatiotemporal dynamics of visual category perception. This revealed initial involvement of sources in the inferior occipital, inferior temporal and superior occipital gyrus. During sustained stimulation additional sources in the anterior inferior temporal gyrus and superior parietal gyrus became involved. We conclude that decoding of source-space MEG data provides a suitable method to investigate the spatiotemporal dynamics of ongoing cognitive processing. TI - MEG-based decoding of the spatiotemporal dynamics of visual category perception EP - 1073 SN - 1053-8119 SP - 1063 JF - NeuroImage VL - vol. 83 PS - 11 p. DO - http://dx.doi.org/10.1016/j.neuroimage.2013.07.075 ER - TY - JOUR AU - Gross, J. AU - Baillet, S. AU - Barnes, G.R. AU - Henson, R.N. AU - Hillebrand, A. AU - Jensen, O. AU - Jerbi, K. AU - Litvak, V. AU - Maess, B. AU - Oostenveld, R. AU - Parkkonen, L. AU - Taylor, J.R. AU - van Wassenhove, V. AU - Wibral, M. AU - Schoffelen, J.-M. PY - 2013 UR - http://hdl.handle.net/2066/122417 TI - Good practice for conducting and reporting MEG research EP - 363 SN - 1053-8119 IS - iss. 0 SP - 349 JF - NeuroImage VL - vol. 65 DO - https://doi.org/10.1016/j.neuroimage.2012.10.001 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/122417/122417.pdf?sequence=1 ER - TY - JOUR AU - Grent-'t Jong, T. AU - Oostenveld, R. AU - Jensen, O. AU - Medendorp, W.P. AU - Praamstra, P. PY - 2013 UR - http://hdl.handle.net/2066/132916 TI - Oscillatory dynamics of response competition in human sensorimotor cortex EP - 34 SN - 1053-8119 SP - 27 JF - NeuroImage VL - vol. 83 DO - https://doi.org/10.1016/j.neuroimage.2013.06.051 ER - TY - JOUR AU - Van Ede, F. AU - Jensen, O. AU - Maris, E.G.G. PY - 2010 UR - http://hdl.handle.net/2066/90355 AB - Neuronal oscillations are postulated to play a fundamental role in top-down processes of expectation. We used magnetoencephalography (MEG) to investigate whether expectation of a tactile event involves a pre-stimulus modulation of neuronal oscillations in human somatosensory cortex. In a bimodal attention paradigm, participants were presented with a predictable spatio-temporal pattern of lateralized tactile stimulations and simultaneously occurring non-lateralized auditory stimuli. Before the onset of a series of such combined audio-tactile stimuli, a cue was presented that indicated the sensory stream that had to be attended. By investigating lateralized patterns of oscillatory activity, we were able to study both attentive (when the tactile stream was attended) and non-attentive (when the auditory stream was attended) tactile expectations. For both attention conditions, we observed a lateralized modulation of the amplitude of beta band oscillations prior to a predictable - and accordingly lateralized - tactile stimulus. As such, we show that anticipatory modulation of ongoing oscillatory activity is not restricted to attended sensory events. Attention did enlarge the size of this modulation. We argue that this modulation constitutes a suppression of beta oscillations that originate at least partly from primary somatosensory cortex (Si) contralateral to the expected stimulation. We discuss our results in the light of the hypothesis that ongoing beta oscillations over sensorimotor cortex reflect a brain state in which neuronal processing efficacy is low. Pre-stimulus suppression of these oscillations then prepares the system for future processing. This shows that perception is an active process that starts even prior to sensation. (C) 2010 Elsevier Inc. All rights reserved. TI - Tactile expectation modulates pre-stimulus beta-band oscillations in human sensorimotor cortex EP - 876 SN - 1053-8119 IS - iss. 2 SP - 867 JF - NeuroImage VL - vol. 51 DO - https://doi.org/10.1016/j.neuroimage.2010.02.053 ER - TY - JOUR AU - Gerven, M.A.J. van AU - Hesse, C. AU - Jensen, O. AU - Heskes, T.M. PY - 2009 UR - http://hdl.handle.net/2066/76140 TI - Interpreting single trial data using groupwise regularisation EP - 676 SN - 1053-8119 IS - iss. 3 SP - 665 JF - NeuroImage VL - vol. 46 PS - 12 p. DO - https://doi.org/10.1016/j.neuroimage.2009.02.041 ER - TY - JOUR AU - Gerven, M.A.J. van AU - Hesse, C. AU - Jensen, O. AU - Heskes, T. PY - 2009 UR - http://hdl.handle.net/2066/101002 TI - Interpreting single trial data using groupwise regularisation EP - 676 SN - 1053-8119 IS - iss. 3 SP - 665 JF - NeuroImage VL - vol. 46 PS - 12 p. DO - https://doi.org/10.1016/j.neuroimage.2009.02.041 ER - TY - JOUR AU - Nieuwenhuis, I.L.C. AU - Takashima, A. AU - Oostenveld, R. AU - Fernandez, G.S.E. AU - Jensen, O. PY - 2008 UR - http://hdl.handle.net/2066/115461 TI - Visual areas become less engaged in associative recall following memory stabilization EP - 1327 SN - 1053-8119 IS - iss. 3 SP - 1319 JF - NeuroImage VL - vol. 40MEG DO - https://doi.org/10.1016/j.neuroimage.2007.12.052 ER - TY - JOUR AU - Nieuwenhuis, I.L.C. AU - Takashima, A. AU - Oostenveld, R. AU - Fernandez, G.S.E. AU - Jensen, O. PY - 2008 UR - http://hdl.handle.net/2066/69445 AB - Numerous studies have focused on changes in the activity in the hippocampus and higher association areas with consolidation and memory stabilization. Even though perceptual areas are engaged in memory recall, little is known about how memory stabilization is reflected in those areas. Using magnetoencephalography (MEG) we investigated changes in visual areas with memory stabilization. Subjects were trained on associating a face to one of eight locations. The first set of associations ('stabilized') was learned in three sessions distributed over a week. The second set ('labile') was learned in one session just prior to the MEG measurement. In the recall session only the face was presented and subjects had to indicate the correct location using a joystick. The MEG data revealed robust gamma activity during recall, which started in early visual cortex and propagated to higher visual and parietal brain areas. The occipital gamma power was higher for the labile than the stabilized condition (time=0.65-0.9 s). Also the event-related field strength was higher during recall of labile than stabilized associations (time=0.59-1.5 s). We propose that recall of the spatial associations prior to memory stabilization involves a top-down process relying on reconstructing learned representations in visual areas. This process is reflected in gamma band activity consistent with the notion that neuronal synchronization in the gamma band is required for visual representations. More direct synaptic connections are formed with memory stabilization, thus decreasing the dependence on visual areas. TI - Visual areas become less engaged in associative recall following memory stabilization. EP - 1327 SN - 1053-8119 IS - iss. 3 SP - 1319 JF - NeuroImage VL - vol. 40 DO - https://doi.org/10.1016/j.neuroimage.2007.12.052 ER -