Stabilization of peptides for intracellular applications by phosphoramidate-linked polyethylene glycol chains.
SourceAngewandte Chemie. International Edition, 52, 45, (2013), pp. 11920-11924
Article / Letter to editor
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Angewandte Chemie. International Edition
SubjectNCMLS 7: Chemical and physical biology
PEG intracellularly! Although long known to enhance residence half-life of peptides in serum and lysates, the effect of PEGylation on biological probes in cells has received only limited attention. Here it is shown that phosphoramidate-linked PEGylated proapoptotic peptides display a dramatically increased stability in Jurkat cell lysate and a homogenous intracellular distribution as well as high apoptotic activity after introduction into cells.
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