Serotonin and aversive Pavlovian control of instrumental behavior in humans
Publication year
2013Number of pages
8 p.
Source
The Journal of Neuroscience, 33, 48, (2013), pp. 18932-18939ISSN
Publication type
Article / Letter to editor

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Organization
Psychiatry
PI Group Motivational & Cognitive Control
Former Organization
Donders Centre for Cognitive Neuroimaging
Journal title
The Journal of Neuroscience
Volume
vol. 33
Issue
iss. 48
Languages used
English (eng)
Page start
p. 18932
Page end
p. 18939
Subject
170 000 Motivational & Cognitive Control; DCN PAC - Perception action and controlAbstract
Adaptive decision-making involves interaction between systems regulating Pavlovian and instrumental control of behavior. Here we investigate in humans the role of serotonin in such Pavlovian-instrumental transfer in both the aversive and the appetitive domain using acute tryptophan depletion, known to lower central serotonin levels. Acute tryptophan depletion attenuated the inhibiting effect of aversive Pavlovian cues on instrumental behavior, while leaving unaltered the activating effect of appetitive Pavlovian cues. These data suggest that serotonin is selectively involved in Pavlovian inhibition due to aversive expectations and have implications for our understanding of the mechanisms underlying a range of affective, impulsive, and aggressive neuropsychiatric disorders.
This item appears in the following Collection(s)
- Academic publications [202802]
- Donders Centre for Cognitive Neuroimaging [3354]
- Electronic publications [100870]
- Faculty of Medical Sciences [80020]
- Open Access publications [69592]
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