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Title: Serotonin and aversive Pavlovian control of instrumental behavior in humans
Author(s): Geurts, D.E.M. ; Huys, Q.J.M.; Ouden, H.E.M. den ; Cools, R.
Publication year: 2013
Source: The Journal of Neuroscience, vol. 33, iss. 48, (2013), pp. 18932-18939
Number of Pages: 8 p.
ISSN: 0270-6474
DOI: https://doi.org/10.1523/JNEUROSCI.2749-13.2013
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/126241   https://hdl.handle.net/2066/126241

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Subject: 170 000 Motivational & Cognitive Control
DCN PAC - Perception action and control
Organization: Psychiatry
PI Group Motivational & Cognitive Control
Former Organization: Donders Centre for Cognitive Neuroimaging
Journal title:
The Journal of Neuroscience
Volume: vol. 33
Issue: iss. 48
Page start: p. 18932
Page end: p. 18939
Abstract:
Adaptive decision-making involves interaction between systems regulating Pavlovian and instrumental control of behavior. Here we investigate in humans the role of serotonin in such Pavlovian-instrumental transfer in both the aversive and the appetitive domain using acute tryptophan depletion, known to lower central serotonin levels. Acute tryptophan depletion attenuated the inhibiting effect of aversive Pavlovian cues on instrumental behavior, while leaving unaltered the activating effect of appetitive Pavlovian cues. These data suggest that serotonin is selectively involved in Pavlovian inhibition due to aversive expectations and have implications for our understanding of the mechanisms underlying a range of affective, impulsive, and aggressive neuropsychiatric disorders.
Languages used: English (eng)

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