Publication year
2013Source
Journal of the American Chemical Society, 135, 39, (2013), pp. 14726-14730ISSN
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Publication type
Article / Letter to editor

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Organization
Tumorimmunology
Journal title
Journal of the American Chemical Society
Volume
vol. 135
Issue
iss. 39
Page start
p. 14726
Page end
p. 14730
Subject
NCMLS 2: Immune RegulationAbstract
The cysteine cathepsins are a family of proteases that play important roles in both normal cellular physiology and many human diseases. In cancer, the activity of many of the cysteine cathepsins is upregulated and can be exploited for tumor imaging. Here we present the design and synthesis of a new class of quenched fluorescent activity-based probes (qABPs) containing a phenoxymethyl ketone (PMK) electrophile. These reagents show enhanced in vivo properties and broad reactivity resulting in dramatically improved labeling and tumor imaging properties compared to those of previously reported ABPs.
This item appears in the following Collection(s)
- Academic publications [202738]
- Faculty of Medical Sciences [79998]
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