Screening for maternal coeliac disease as a potential risk factor for orofacial clefts--a pilot study
SourceInternational Journal of Oral and Maxillofacial Surgery, 42, 11, (2013), pp. 1424-1426
Article / Letter to editor
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Oral and Maxillofacial Surgery
International Journal of Oral and Maxillofacial Surgery
SubjectNCEBP 2: Evaluation of complex medical interventions
There is increasing evidence that dietary folic acid deficiency in utero may increase the risk of developing the 'cleft lip with or without cleft palate' (CL+/-P) variant of orofacial cleft. Coeliac disease is a common cause of folic acid malabsorption, and in the majority of cases remains undiagnosed. This pilot study assessed the seroprevalence of undiagnosed coeliac disease in a cohort of mothers of infants with CL+/-P in the Hyderabad area of India. The seroprevalence of coeliac disease of 1.15% (95% confidence interval 0.37-2.66%) was little different from the expected figure based on published population studies, making a clinically significant association unlikely.
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