Characterisation of CMP-sialic acid transporter substrate recognition
SourceChemBioChem, 14, 15, (2013), pp. 1936-42
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
SubjectDCN MP - Plasticity and memory; DCN PAC - Perception action and control IGMD 4: Glycostation disorders
CMP-sialic acid transporter: We report an in-depth, multidisciplinary, structural study that has identified the amino acid residues intimately involved in CMP-sialic acid transporter (CST) substrate specificity. Our data provide a significant contribution towards a better understanding the structure-function relationship of this important family of transporters and the rational design of CST inhibitors.
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