Publication year
2013Source
Current Opinion in Pharmacology, 13, 6, (2013), pp. 853-8ISSN
Annotation
01 december 2013
Publication type
Article / Letter to editor
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Organization
Physiology
Journal title
Current Opinion in Pharmacology
Volume
vol. 13
Issue
iss. 6
Page start
p. 853
Page end
p. 8
Subject
NCMLS 5: Membrane transport and intracellular motility IGMD 9: Renal disorderAbstract
Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them. These studies showed that Multidrug resistance-associated protein 2 (Mrp2) can limit intestinal drug absorption. Organic cation transporter n1 (Octn1) and Octn2 might also facilitate intestinal drug absorption, although direct in vivo evidence is lacking. On the other hand, intestinal uptake of drugs is facilitated by the Equilibrative nucleoside transporter 1 (Ent1), Mrp3 and possibly Mrp4. No significant role in intestinal absorption for Oct1 and Oct2 or for Organic anion-transporting polypeptides (Oatp) 1a and 1b was found so far.
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- Faculty of Medical Sciences [90373]
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