Publication year
2013Source
Seminars in Immunology, 25, 6, (2013), pp. 458-65ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Internal Medicine
Journal title
Seminars in Immunology
Volume
vol. 25
Issue
iss. 6
Page start
p. 458
Page end
p. 65
Subject
N4i 1: Pathogenesis and modulation of inflammation; N4i 2: Invasive mycoses and compromised hostAbstract
IL-36alpha, IL-36beta, IL-36gamma, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36alpha, IL-36beta, and IL-36gamma are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling. IL-36 cytokines require processing in order to become fully active, however the protease(s) responsible for this are currently not known. The IL-36 receptor pathway activates dendritic cells and plays a role in polarizing T-helper responses. The skin is the predominant site where IL-36 cytokines are expressed and several reports have established that they play a significant role in the pathogenesis of skin diseases. In this review the discovery and biological function of the cytokines IL-36alpha, IL-36beta, IL-36gamma and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety of diseases.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.