Isolation of non-tuberculous mycobacteria at three rural settings in Zambia; a pilot study.

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Title:	Isolation of non-tuberculous mycobacteria at three rural settings in Zambia; a pilot study.
Author(s):	Buijtels, P.C.; Sande, M.A.B. van der ; Parkinson, S.; Verbrugh, H.A.; Petit, P.L.; Soolingen, D. van
Publication year:	2010
Source:	Clinical Microbiology and Infection, vol. 16, iss. 8, (2010), pp. 1142-1148
ISSN:	1198-743X
DOI:	https://doi.org/10.1111/j.1469-0691.2009.03072.x
Annotation:	1 augustus 2010
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/124336
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Subject:	N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity
Organization:	Internal Medicine Medical Microbiology
Journal title:	Clinical Microbiology and Infection
Volume:	vol. 16
Issue:	iss. 8
Page start:	p. 1142
Page end:	p. 1148
Abstract:	To assess the role of non-tuberculous mycobacteria (NTM) as a cause of tuberculosis-like diseases in Zambia, 167 chronically ill patients, hospitalized in three rural hospitals in Katete, Sesheke and Chilonga, were examined by microscopy and liquid culture for the presence of NTM. The percentages of patients with a positive culture for Mycobacterium tuberculosis complex were similar in the three geographical locations (19-25%). In contrast, the percentage of NTM ranged from 78% in Katete and 65% in Sesheke to 21% in Chilonga. Furthermore, the distribution of NTM species was different at the three geographical sites. In seven patients, true NTM-associated disease was suspected: five with Mycobacterium lentiflavum and two with Mycobacterium intracellulare. Analysis of possible risk factors indicated that the OR for NTM culture-positive sputum was significantly higher for patients living in Katete and Sesheke. Female gender and chest X-ray appearances of tuberculosis were independently associated with NTM culture-positive sputum. NTM colonization and disease in hospitalized, chronically ill patients in rural Zambia appear to be common.